Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7299
Gene Symbol: TYR
TYR 		0.110 GeneticVariation disease BEFREE Worse best-corrected visual acuity and higher mean astigmatism at visit C were found for OCA1A (20/104 and +4.08 ± 1.34) compared to OCA1B (20/59 and +2.30 ± 1.36; P < 0.0001) and OCA2 (20/66 and +2.53 ±1.21; P < 0.0001). 30343058 2018
Entrez Id: 401237
Gene Symbol: CASC15
CASC15 		0.110 Biomarker disease BEFREE Three of these loci also demonstrated genome-wide significant association with refractive astigmatism: LINC00340, HERC2/OCA2 and NPLOC4/TSPAN10. 30306274 2018
Entrez Id: 401237
Gene Symbol: CASC15
CASC15 		0.110 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 401237
Gene Symbol: CASC15
CASC15 		0.110 GeneticVariation disease GWASCAT Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. 25367360 2015
Entrez Id: 778
Gene Symbol: CACNA1F
CACNA1F 		0.110 Biomarker disease BEFREE Clinically, CORDX3 shares some features with CSNB2 but is distinguishable from CSNB2 in that it is progressive, can begin in adulthood, has no nystagmus or hyperopic refraction, has only low grade astigmatism, and in dark adaptation lacks cone threshold and has small or no elevation of rod threshold. 16505158 2006
Entrez Id: 7299
Gene Symbol: TYR
TYR 		0.110 Biomarker disease HPO
Entrez Id: 778
Gene Symbol: CACNA1F
CACNA1F 		0.110 Biomarker disease HPO
Entrez Id: 56947
Gene Symbol: MFF
MFF 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 26146
Gene Symbol: TRAF3IP1
TRAF3IP1 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 100505832
Gene Symbol: PROX1-AS1
PROX1-AS1 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 55666
Gene Symbol: NPLOC4
NPLOC4 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 8924
Gene Symbol: HERC2
HERC2 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 129049
Gene Symbol: SGSM1
SGSM1 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 84181
Gene Symbol: CHD6
CHD6 		0.100 GeneticVariation disease GWASCAT Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. 30306274 2018
Entrez Id: 206338
Gene Symbol: LVRN
LVRN 		0.100 GeneticVariation disease GWASCAT Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. 25367360 2015
Entrez Id: 1767
Gene Symbol: DNAH5
DNAH5 		0.100 GeneticVariation disease GWASCAT Identification of a candidate gene for astigmatism. 23322567 2013
Entrez Id: 25806
Gene Symbol: VAX2
VAX2 		0.100 GeneticVariation disease GWASCAT Identification of a candidate gene for astigmatism. 23322567 2013
Entrez Id: 105369723
Gene Symbol: LINC02422
LINC02422 		0.100 GeneticVariation disease GWASCAT Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study. 23761726 2013
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. 22144915 2011
Entrez Id: 51450
Gene Symbol: PRRX2
PRRX2 		0.100 GeneticVariation disease GWASCAT Web-based, participant-driven studies yield novel genetic associations for common traits. 20585627 2010
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11 		0.100 CausalMutation disease CLINVAR Diverse driving forces underlie the invariant occurrence of the T42A, E139D, I282V and T468M SHP2 amino acid substitutions causing Noonan and LEOPARD syndromes. 18372317 2008
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11 		0.100 CausalMutation disease CLINVAR Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease. 16358218 2006
Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11 		0.100 CausalMutation disease CLINVAR PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. 11992261 2002
Entrez Id: 29089
Gene Symbol: UBE2T
UBE2T 		0.100 Biomarker disease HPO