Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE Furthermore, studies of colorectal cancer specimens indicated that the expression of miR-26b and Pgp had inverse correlation. 30662808 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE Genotyping of ABCB1 variants can help to prevent severe adverse reactions to irinotecan-based treatments in colorectal cancer. 30213564 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE We investigated the impact of ABCB1 genetic variants on colorectal cancer (CRC) risk. 22396794 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease CTD_human The role of ABC transporters in progression and clinical outcome of colorectal cancer. 22294766 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE Moreover, a significantly positive association between RARγ and MDR1 was demonstrated in CRC tissue microarrays. 28272990 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE Visfatin mediates doxorubicin resistance in human colorectal cancer cells via up regulation of multidrug resistance 1 (MDR1). 28667355 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1. 30439718 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE Pgp expression was not associated with either p53 expression (P = 0.73) or incidence of p53 gene mutation (P = 0.70), suggesting that mutant p53 does not induce Pgp overexpression in colorectal carcinomas. 7640210 1995
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE This study suggests that low ABCB1 mRNA levels are an early event in CRC development and that the two polymorphisms affect ABCB1 mRNA levels whereas low NFKB1 mRNA levels occur later in carcinogenesis. 23977225 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE However, it is unclear whether similar mechanisms of doxorubicin resistance are involved in colorectal cancer (CRC). 29701752 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE Effect of ionizing radiation on transcription of colorectal cancer MDR1 gene of HCT-8 cells. 23608383 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE Using a case-control design, the association between the MDR1 intron 3 G-rs3789243-A polymorphism and the risk of colorectal carcinomas and adenomas in the Norwegian population was assessed in 167 carcinomas, 990 adenomas, and 400 controls. 19250544 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE However, a smoking and age-stratified analysis, revealed a statistically significant association between MDR1 genotypes and colorectal cancer in life-long non-smokers with an age > or =63 years (the median age in our sample). 17146660 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE There was interaction between these MDR1 polymorphisms and intake of red and processed meat in relation to CRC risk. 19930591 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE We aimed to investigate the effect of MDR1 polymorphisms on its expression level and related characteristics in Iranian colorectal cancer patients. 22394004 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE These findings implicate a role of ESR2 in the risk for developing CRC in women and suggest that HSD17B1, ABCB1, and SHBG genes may contribute to sex steroid-mediated effects on CRC development. 21317201 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans. 16800822 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE AFP promoter-driven anti-MDR1 ribozymes reduced the IC(50) 30-fold for epirubicin in HCC cells, whereas human colorectal cancer cells were unaffected. 12297834 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE In this study, the potential role of SNPs of the ABCB1/MDR1 gene as a prognostic marker for CRC was analysed. 20533057 2010
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE Chemoresistance in multidrug-resistant (MDR) cells over expressing P-glycoprotein (P-gp) encoded by the MDR1 gene, is a major obstacle to successful chemotherapy for colorectal cancer. 24901713 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE The expressions of MDR-associated protein topoisomerase II (Topo II) and P-glycoprotein (P-gp) in CRC tissues were detected by immunohistochemistry. 28816939 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE Collectively, the results of the present study suggest that there were no significant associations of ABCB1/MDR1 C3435T polymorphism with colorectal cancer observed for all comparison models. 23504525 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 AlteredExpression disease BEFREE These results suggest that the mdr-1 mRNA expression in gastric and colorectal cancers is related to the degree of cellular differentiation. 9677442 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 GeneticVariation disease BEFREE We showed that ABCB1 polymorphisms were able to influence CRC susceptibility related to tumor localization and patient gender. 25355168 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1 		0.600 Biomarker disease BEFREE The present study provides additional evidence for the role that the MDR1/ABCB1 gene plays in the initiation and progression of MSI-H CRC development. 18474294 2008