Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD 		0.010 GeneticVariation disease BEFREE SLE may be a novel phenotype of GOF mutation in PI3CKD gene (GOF PIK3CD). 31045771 2019
Entrez Id: 618
Gene Symbol: BCYRN1
BCYRN1 		0.010 Biomarker disease BEFREE SLE anti-BC abs belong to the IgG class of immunoglobulins and target both primate BC200 RNA and rodent BC1 RNA. 31405929 2019
Entrez Id: 3183
Gene Symbol: HNRNPC
HNRNPC 		0.010 Biomarker disease BEFREE SLE anti-BC abs effectively compete with RNA transport factor heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) for DTE access and significantly diminish BC RNA delivery to synapto-dendritic sites of function. 31405929 2019
Entrez Id: 9987
Gene Symbol: HNRNPDL
HNRNPDL 		0.010 Biomarker disease BEFREE SLE anti-BC abs effectively compete with RNA transport factor heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) for DTE access and significantly diminish BC RNA delivery to synapto-dendritic sites of function. 31405929 2019
Entrez Id: 7297
Gene Symbol: TYK2
TYK2 		0.040 GeneticVariation disease BEFREE SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500. 31434951 2019
Entrez Id: 114086
Gene Symbol: DBA2
DBA2 		0.010 Biomarker disease BEFREE SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibody expressing the 16/6Id, to which the DBA/2 strain is susceptible (responder) and the C57BL/6 strain is resistant (nonresponder); and (2) induction of autoimmune GVHD in B6D2F1 hosts by inoculation of parental DBA/2 (induces SLE) or C57BL/6 (does not induce SLE) T cells. 9325066 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.040 GeneticVariation disease BEFREE Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. 12043886 2002
Entrez Id: 3606
Gene Symbol: IL18
IL18 		0.050 Biomarker disease BEFREE IL-18 is therefore suggested to play a crucial role in the inflammatory processes of renal disease in SLE. 12390326 2002
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.090 Biomarker disease BEFREE IL10/TNFalpha interaction influences susceptibility to DLE and the appearance of specific autoantibodies in SLE patients, whereas high TNFalpha producer genotypes represent a significant risk factor for SLE. 15800006 2005
Entrez Id: 10461
Gene Symbol: MERTK
MERTK 		0.010 GeneticVariation disease BEFREE MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients. 16837475 2007
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22 		0.050 Biomarker disease BEFREE PTPN22: its role in SLE and autoimmunity. 18075792 2007
Entrez Id: 3606
Gene Symbol: IL18
IL18 		0.050 GeneticVariation disease BEFREE IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE. 19387647 2009
Entrez Id: 553128
Gene Symbol: KIR2DL5B
KIR2DL5B 		0.010 GeneticVariation disease BEFREE KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. 20371502 2010
Entrez Id: 57292
Gene Symbol: KIR2DL5A
KIR2DL5A 		0.010 GeneticVariation disease BEFREE KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. 20371502 2010
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.060 Biomarker disease BEFREE HLA-DRB1*15 confers susceptibility to juvenile SLE but is not associated with disease presentation: an Egyptian Study. 20380521 2010
Entrez Id: 114836
Gene Symbol: SLAMF6
SLAMF6 		0.010 Biomarker disease BEFREE SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. 21231893 2011
Entrez Id: 4783
Gene Symbol: NFIL3
NFIL3 		0.010 AlteredExpression disease BEFREE E4BP4 overexpression: a protective mechanism in CD4+ T cells from SLE patients. 23340290 2013
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22 		0.050 GeneticVariation disease BEFREE PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results. 24985973 2014
Entrez Id: 6375
Gene Symbol: XCL1
XCL1 		0.010 Biomarker disease BEFREE ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells. 27249108 2016
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.030 GeneticVariation disease BEFREE BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares. 27864698 2017
Entrez Id: 9447
Gene Symbol: AIM2
AIM2 		0.020 Biomarker disease BEFREE Absent in Melanoma 2 proteins in SLE. 28062222 2017
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3 		0.020 AlteredExpression disease BEFREE TNFAIP3 mRNA was significantly downregulated in the CD4 + T cells of SLE patients compared with NCs. 28158872 2017
Entrez Id: 6777
Gene Symbol: STAT5B
STAT5B 		0.010 PosttranslationalModification disease BEFREE STAT5 phosphorylation in CD4 T cells from patients with SLE is related to changes in their subsets and follow-up disease severity. 28254841 2017
Entrez Id: 6776
Gene Symbol: STAT5A
STAT5A 		0.010 PosttranslationalModification disease BEFREE STAT5 phosphorylation in CD4 T cells from patients with SLE is related to changes in their subsets and follow-up disease severity. 28254841 2017
Entrez Id: 442896
Gene Symbol: MIR302D
MIR302D 		0.010 AlteredExpression disease BEFREE MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE. 28318807 2017