×
Entrez Id:
6857
Gene Symbol:
SYT1
SYT1
0.010
AlteredExpression
disease
BEFREE
SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2.
12027419
2002
×
Entrez Id:
65125
Gene Symbol:
WNK1
WNK1
0.010
AlteredExpression
disease
BEFREE
SLE T cells have been shown to display low levels of the p65 subunit of the NF-kappaB transcription factor and decreased production of IL-2.
12027419
2002
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
A highly significant increase in the frequency of DRB1 *1502 and DQB1*0501 was found in SLE patients compared with normal controls.
12028537
2002
×
Entrez Id:
129831
Gene Symbol:
RBM45
RBM45
0.020
GeneticVariation
disease
BEFREE
A highly significant increase in the frequency of DRB1 *1502 and DQB1*0501 was found in SLE patients compared with normal controls.
12028537
2002
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
0.040
GeneticVariation
disease
BEFREE
Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE .
12043886
2002
×
Entrez Id:
581
Gene Symbol:
BAX
BAX
0.010
AlteredExpression
disease
BEFREE
A rise in the expression of the pro-apoptotic bax gene was detected specifically in the SLEV -infected K562 cells.
12111422
2002
×
Entrez Id:
1636
Gene Symbol:
ACE
ACE
0.040
GeneticVariation
disease
BEFREE
Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families.
12215901
2002
×
Entrez Id:
27352
Gene Symbol:
SGSM3
SGSM3
0.010
AlteredExpression
disease
BEFREE
Constitutive up-regulated activity of MAP kinase is associated with down-regulated early p21Ras pathway in lymphocytes of SLE patients.
12367560
2003
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
0.010
Biomarker
disease
BEFREE
Early p21Ras signalling was down-regulated in SLE patients with active disease as indicated by the decreased membrane/cytoplasmic (M/C) ratios of the p21Ras regulatory elements hSOS1 and p120GAP and by the non-responsiveness of these ratios to cellular stimulation.
12367560
2003
×
Entrez Id:
5921
Gene Symbol:
RASA1
RASA1
0.010
AlteredExpression
disease
BEFREE
Levels of p21Ras stimulatory element hSOS1 but not p21Ras and its inhibitory element p120GAP were significantly decreased in SLE patients.
12367560
2003
×
Entrez Id:
6631
Gene Symbol:
SNRPC
SNRPC
0.010
Biomarker
disease
BEFREE
SLE patient sera were positive for reactivity to: U1snRNP-C , 4/15 (27%); alpha-enolase, 1/15 (7%); RPS20, 3/15 (20%); RPS13, 1/15 (7%); PIC1, 1/15 (7%); and MRG15, 2/15 (13%).
12379236
2002
×
Entrez Id:
3606
Gene Symbol:
IL18
IL18
0.050
Biomarker
disease
BEFREE
IL-18 is therefore suggested to play a crucial role in the inflammatory processes of renal disease in SLE .
12390326
2002
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
0.070
GeneticVariation
disease
BEFREE
The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE .
12460032
2002
×
Entrez Id:
3151
Gene Symbol:
HMGN2
HMGN2
0.010
Biomarker
disease
BEFREE
SLE sera positive for HMG-17 had also cross reactivity with H1, and following the same procedure as before we received HMG-17 specific SLE autoantibodies and anti-HMG-17/H1 autoantibodies.
12523645
2002
×
Entrez Id:
6709
Gene Symbol:
SPTAN1
SPTAN1
0.010
Biomarker
disease
BEFREE
Autoantibodies to alpha-fodrin in primary Sjögren's syndrome and SLE detected by an in vitro transcription and translation assay.
12673889
2003
×
Entrez Id:
959
Gene Symbol:
CD40LG
CD40LG
0.040
AlteredExpression
disease
BEFREE
Furthermore, CD40L expression on T cells upon activation was enhanced in SLE patients.
12673892
2003
×
Entrez Id:
1235
Gene Symbol:
CCR6
CCR6
0.020
Biomarker
disease
BEFREE
The cell surface expression of the chemokine receptors CXCR5 and CCR6 was decreased in SLE patients compared with controls (P = 0.051 and P = 0.002, respectively).
14596426
2003
×
Entrez Id:
6352
Gene Symbol:
CCL5
CCL5
0.010
AlteredExpression
disease
BEFREE
The levels of the chemokines MIP-1alpha MCP-1, SDF-1alpha, IP-10 and RANTES were significantly elevated in SLE patients compared with controls.
14596426
2003
×
Entrez Id:
643
Gene Symbol:
CXCR5
CXCR5
0.010
Biomarker
disease
BEFREE
The decrease of CXCR5 was confined to SLE patients with inactive disease (SLEDAI < 6) compared with active disease (SLEDAI > 6) and controls.
14596426
2003
HLA-DRB1
0.060
GeneticVariation
disease
BEFREE
SLE -SS patients had a high frequency of the DRB1 *0301 allele.
15022331
2004
×
Entrez Id:
129831
Gene Symbol:
RBM45
RBM45
0.020
GeneticVariation
disease
BEFREE
SLE -SS patients had a high frequency of the DRB1 *0301 allele.
15022331
2004
×
Entrez Id:
970
Gene Symbol:
CD70
CD70
0.030
AlteredExpression
disease
BEFREE
SLE T cells and T cells treated with DNA methylation inhibitors overexpressed CD70 and overstimulated B cell IgG production.
15188362
2004
×
Entrez Id:
5594
Gene Symbol:
MAPK1
MAPK1
0.010
Biomarker
disease
BEFREE
SLE T cells and T cells treated with DNA methyltransferase inhibitors and ERK pathway inhibitors overexpress CD70.
15188362
2004
×
Entrez Id:
2048
Gene Symbol:
EPHB2
EPHB2
0.010
Biomarker
disease
BEFREE
SLE T cells and T cells treated with DNA methyltransferase inhibitors and ERK pathway inhibitors overexpress CD70.
15188362
2004
×
Entrez Id:
919
Gene Symbol:
CD247
CD247
0.040
AlteredExpression
disease
BEFREE
We have demonstrated that the expression of TCR zeta chain is significantly decreased in peripheral blood T cells from SLE patients.
15204089
2005