Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE These mutations co-occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor protein 53 (TP53) and alpha thalassemia/mental retardation (ATRX) mutations, which together help to define a molecular signature that aids in the classification of gliomas and helps to better predict clinical behavior. 28980701 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE H3.3<sup>K27M</sup> Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas. 29107533 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Gliomas with mutant p53 occurring in 30% of glioma patients exhibit therapeutic resistance and poor outcomes. 28775165 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Cathepsin L is involved in modulation of radiosensitivity in human glioma U251 cells (harboring the mutant type p53 gene) in vitro. 26095040 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE PCR-based mutation analyses of IDH and TP53 were sufficient for simple genetic diagnosis of glioma that were strongly associated with prognosis of patients and enabled us to detect negative CNAs in IDH mutant gliomas. 26558387 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE The presence of the K27M mutation significantly corresponded with mutations in TP53 in thalamic gliomas. 26297251 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE One on chromosome 8 increases risk of IDH-mutated gliomas sixfold and another that affects TP53 function confers a 2.5-fold increased risk of glioma. 26948345 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Pharmacological ATM inhibition also reduced Pdgfra expression, and reduced the proliferation of Trp53-deficient primary glioma cells from murine and human tumors, while normal neural stem cells were unaffected. 26984279 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Immunohistochemistry on IDH 1/2, ATRX, p53 and Ki-67 substitute molecular genetic testing and predict patient prognosis in grade III adult diffuse gliomas. 26968173 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1). 25713050 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells. 26892186 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data. 25907361 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Revisiting TP53 Mutations and Immunohistochemistry--A Comparative Study in 157 Diffuse Gliomas. 25040820 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. 26470725 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas. 26676363 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Clinical information and genetic data including isocitrate dehydrogenase 1 mutation, O 6-methylguanine DNA methyltransferase promoter methylation, 1p/19q chromosome loss, and TP53 mutation of 417 low-grade gliomas were collected from the Chinese Glioma Genome Atlas database. 26115094 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE Exposure to small doses of irradiation, Trib1 formed a complex with pHDAC1 (phosphor histone deacetylase-1) to inhibit p53 expression in glioma cells. 26521947 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Our results indicate that the loss of p53 by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance. 24862407 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 AlteredExpression disease BEFREE These results showed that SMYD3 is overexpressed in human glioma and contributes to glioma tumorigenicity through p53. 26328527 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Reactive oxygen species (ROS) production was required for salinomycin-induced p53 mitochondrial translocation, mPTP opening and necrosis, and anti-oxidants n-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) inhibited p53 translocation, mPTP opening and glioma cell death. 26024660 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Our analysis also identified PI3-kinase mutations as markers of poor prognosis in IDH-mutated + ATRX/TP53 mutated diffuse gliomas, median survival 3.7 v. 6.3 years (P = 0.02, Hazard rate (HR) 2.93, 95 % confidence interval (CI) 1.16 - 7.38). 26699864 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 GeneticVariation disease BEFREE Nearly all lower-grade gliomas with IDH mutations and no 1p/19q codeletion had mutations in TP53 (94%) and ATRX inactivation (86%). 26061751 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE In support of the functional interaction between CD24 and p53, in silico analyses reveal that TP53 mutates at a higher rate among glioma and prostate cancer samples with higher CD24 mRNA levels. 25600590 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.900 Biomarker disease BEFREE Furthermore, AND did not induce apoptosis or activate ERK and p53 in primary cultured astrocyte cells, and it may serve as a potential therapeutic candidate for the treatment of glioma. 25162007 2015