Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M 		0.200 Biomarker phenotype RGD Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. 12494268 2003
Entrez Id: 10060
Gene Symbol: ABCC9
ABCC9 		0.100 Biomarker phenotype HPO
Entrez Id: 34
Gene Symbol: ACADM
ACADM 		0.100 Biomarker phenotype HPO
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.220 GeneticVariation phenotype LHGDN Influence of ACE I/D genotypes on left ventricular hypertrophy in aortic stenosis: gender-related differences. 15311863 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.220 Therapeutic phenotype RGD Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. 24342267 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE 		0.220 Biomarker phenotype LHGDN Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats. 15128700 2004
Entrez Id: 10965
Gene Symbol: ACOT2
ACOT2 		0.200 Biomarker phenotype RGD Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. 15292030 2004
Entrez Id: 59
Gene Symbol: ACTA2
ACTA2 		0.100 Biomarker phenotype HPO
Entrez Id: 103
Gene Symbol: ADAR
ADAR 		0.100 Biomarker phenotype HPO
Entrez Id: 133
Gene Symbol: ADM
ADM 		0.020 Biomarker phenotype LHGDN Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats. 16115629 2005
Entrez Id: 133
Gene Symbol: ADM
ADM 		0.020 Biomarker phenotype LHGDN Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure. 15974887 2005
Entrez Id: 147
Gene Symbol: ADRA1B
ADRA1B 		0.300 Biomarker phenotype CTD_human Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor. 11278430 2001
Entrez Id: 147
Gene Symbol: ADRA1B
ADRA1B 		0.300 Biomarker phenotype CTD_human Cardiovascular influences of alpha1b-adrenergic receptor defect in mice. 11940550 2002
Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A 		0.300 Therapeutic phenotype CTD_human Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. 20083574 2010
Entrez Id: 152
Gene Symbol: ADRA2C
ADRA2C 		0.300 Biomarker phenotype CTD_human Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. 20083574 2010
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Biomarker phenotype CTD_human Heme oxygenase-1 inhibits angiotensin II-induced cardiac hypertrophy in vitro and in vivo. 15226216 2004
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Therapeutic phenotype CTD_human Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy. 17124262 2007
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Therapeutic phenotype CTD_human Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR(A1-7)3292 rats. 20409916 2013
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Therapeutic phenotype CTD_human SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. 27099261 2017
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Biomarker phenotype CTD_human Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling. 31016362 2019
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Biomarker phenotype CTD_human Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. 22335191 2013
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Therapeutic phenotype CTD_human Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure. 20811386 2010
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Therapeutic phenotype CTD_human Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. 25139994 2014
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Biomarker phenotype RGD Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. 21367774 2011
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.500 Therapeutic phenotype CTD_human Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. 22335191 2013