Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.010 PosttranslationalModification phenotype LHGDN A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. 19060905 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.010 Biomarker phenotype LHGDN [P53 and its role in the development of heart failure]. 18464525 2008
Entrez Id: 26524
Gene Symbol: LATS2
LATS2 		0.010 Biomarker phenotype LHGDN Lats2 is a negative regulator of myocyte size in the heart. 18927464 2008
Entrez Id: 817
Gene Symbol: CAMK2D
CAMK2D 		0.010 Biomarker phenotype LHGDN Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. 17179159 2007
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.010 AlteredExpression phenotype LHGDN Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy. 17098823 2007
Entrez Id: 9759
Gene Symbol: HDAC4
HDAC4 		0.010 Biomarker phenotype LHGDN Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. 17179159 2007
Entrez Id: 51778
Gene Symbol: MYOZ2
MYOZ2 		0.010 GeneticVariation phenotype LHGDN Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. 17347475 2007
Entrez Id: 6314
Gene Symbol: ATXN7
ATXN7 		0.010 Biomarker phenotype LHGDN Massive SCA7 expansion detected in a 7-month-old male with hypotonia, cardiomegaly, and renal compromise. 17254003 2007
Entrez Id: 7414
Gene Symbol: VCL
VCL 		0.010 AlteredExpression phenotype LHGDN Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc. 16949038 2006
Entrez Id: 5532
Gene Symbol: PPP3CB
PPP3CB 		0.010 AlteredExpression phenotype LHGDN Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes. 15557343 2005
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2 		0.010 GeneticVariation phenotype LHGDN Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2. 15894890 2005
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A 		0.010 GeneticVariation phenotype LHGDN Role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks. 16061744 2005
Entrez Id: 142
Gene Symbol: PARP1
PARP1 		0.010 Biomarker phenotype LHGDN Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure. 15374823 2005
Entrez Id: 10000
Gene Symbol: AKT3
AKT3 		0.010 AlteredExpression phenotype LHGDN Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. 15698844 2005
Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1 		0.010 Biomarker phenotype LHGDN Circulating soluble vascular cell adhesion molecule 1: relationships with residual renal function, cardiac hypertrophy, and outcome of peritoneal dialysis patients. 15806475 2005
Entrez Id: 10971
Gene Symbol: YWHAQ
YWHAQ 		0.010 AlteredExpression phenotype LHGDN Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes. 15930726 2005
Entrez Id: 7068
Gene Symbol: THRB
THRB 		0.010 GeneticVariation phenotype LHGDN Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. 14684607 2004
Entrez Id: 2549
Gene Symbol: GAB1
GAB1 		0.010 AlteredExpression phenotype LHGDN Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes. 12855672 2003
Entrez Id: 4776
Gene Symbol: NFATC4
NFATC4 		0.010 GeneticVariation phenotype LHGDN Polymorphisms of genes of the cardiac calcineurin pathway and cardiac hypertrophy. 12939651 2003
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.010 Biomarker phenotype LHGDN Increased C-reactive protein following hemodialysis predicts cardiac hypertrophy in chronic hemodialysis patients. 12460042 2002
Entrez Id: 7137
Gene Symbol: TNNI3
TNNI3 		0.020 GeneticVariation phenotype LHGDN Familial hypertrophic cardiomyopathy associated with cardiac beta-myosin heavy chain and troponin I mutations. 18175163 2008
Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1 		0.020 AlteredExpression phenotype LHGDN Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1. 18508719 2008
Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1 		0.020 AlteredExpression phenotype LHGDN Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. 18776042 2008
Entrez Id: 7137
Gene Symbol: TNNI3
TNNI3 		0.020 GeneticVariation phenotype LHGDN Prevalence and spectrum of mutations in the sarcomeric troponin T and I genes in a cohort of Spanish cardiac hypertrophy patients. 17101185 2007
Entrez Id: 133
Gene Symbol: ADM
ADM 		0.020 Biomarker phenotype LHGDN Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats. 16115629 2005