Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.310 Biomarker disease CTD_human Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function. 19168511 2009
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2 		0.310 Biomarker disease CTD_human Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure. 15722665 2005
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.310 GeneticVariation disease BEFREE Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients. 29718770 2019
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.310 Biomarker disease CTD_human Isoproterenol-induced heart failure in the rat is associated with nitric oxide-dependent functional alterations of cardiac function. 19168511 2009
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2 		0.310 Biomarker disease CTD_human Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. 21321305 2011
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2 		0.310 Biomarker disease BEFREE Several large clinical studies have demonstrated the important benefit of mineralocorticoid receptor (MR) antagonists in patients with heart failure, left ventricular dysfunction after myocardial infarction, hypertension or diabetic nephropathy. 21784127 2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.310 GeneticVariation disease BEFREE DNA samples from 118 patients with HF-PH were genotyped for the NOS3 rs1799983 and NOS2 rs3730017 polymorphisms. 29718770 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.310 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
Entrez Id: 5502
Gene Symbol: PPP1R1A
PPP1R1A 		0.300 Therapeutic disease CTD_human Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. 20071777 2010
Entrez Id: 152
Gene Symbol: ADRA2C
ADRA2C 		0.300 Biomarker disease CTD_human Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. 12374873 2002
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.300 Biomarker disease CTD_human Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure. 15732037 2005
Entrez Id: 156
Gene Symbol: GRK2
GRK2 		0.300 Biomarker disease CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611 2016
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA 		0.300 Biomarker disease CTD_human Hypereosinophilic Syndrome as a Rare Cause of Reversible Biventricular Heart Failure. 28347583 2017
Entrez Id: 3315
Gene Symbol: HSPB1
HSPB1 		0.300 Therapeutic disease CTD_human Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice. 17481944 2007
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.300 Biomarker disease CTD_human Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure. 15732037 2005
Entrez Id: 6659
Gene Symbol: SOX4
SOX4 		0.300 Biomarker disease CTD_human A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart. 29394407 2018
Entrez Id: 6647
Gene Symbol: SOD1
SOD1 		0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.300 Biomarker disease CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987 2018
Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1 		0.300 Biomarker disease CTD_human Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress? 19027022 2009
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		0.300 Biomarker disease CTD_human Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. 12963636 2003
Entrez Id: 4879
Gene Symbol: NPPB
NPPB 		0.300 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
Entrez Id: 4879
Gene Symbol: NPPB
NPPB 		0.300 Therapeutic disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
Entrez Id: 4878
Gene Symbol: NPPA
NPPA 		0.300 Biomarker disease CTD_human Use of natriuretic peptides for detecting cardiac dysfunction in long-term disease-free breast cancer survivors. 16101196 2005
Entrez Id: 7132
Gene Symbol: TNFRSF1A
TNFRSF1A 		0.300 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
Entrez Id: 4878
Gene Symbol: NPPA
NPPA 		0.300 Biomarker disease CTD_human Mechanisms of sodium retention in heart failure: relation to the renin-angiotensin-aldosterone system. 1647690 1991