Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Outcomes measured included the Oswestry Disability Index (ODI), NRS scales for back and leg pain (NRS-B/NRS-L), CSORN questions pertaining to patient satisfaction with surgery and whether or not the surgery met expectations. 30471460 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 Biomarker phenotype BEFREE While tonic stimulation reduced leg pain (p < 0.05), the burst mode added an extra pain reduction (ΔNRS 1.2 ± 1.5) (p < 0.01). 30328646 2019
Entrez Id: 5251
Gene Symbol: PHEX
PHEX
0.100 CausalMutation phenotype CLINVAR
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.010 GeneticVariation phenotype BEFREE Gait disturbance and lower limb pain in a patient with PIK3CA-related disorder. 28867506 2017
Entrez Id: 8575
Gene Symbol: PRKRA
PRKRA
0.100 Biomarker phenotype HPO
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE Demographics, alignment, and SRS-Schwab modifiers were assessed with χ/paired t tests to compare HRQLs: Scoliosis Research Society 22-question Questionnaire (SRS-22), Numeric Rating Scale (NRS) Back/Leg Pain, Oswestry Disability Index (ODI). 31651683 2020
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE Perioperative spinal deformity parameters, complications, and HRQoL outcome scores (Oswestry Disability Index [ODI], Scoliosis Research Society 22-question Questionnaire [SRS-22], 36-Item Short Form Health Survey [SF-36], visual analog scale [VAS] for back/leg pain) from each group were assessed and compared with each other using ANOVA. 29087808 2018
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 Biomarker phenotype BEFREE PROMs analyzed were the Short Form-12 Physical Component Score (PCS-12), Mental Component Score (MCS-12), Oswestry Disability Index (ODI), and Visual Analog Scale (VAS) Back and Leg pain scores. 31770335 2020
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE Perioperative spinal deformity parameters, complications, and HRQoL outcome scores (Oswestry Disability Index [ODI], Scoliosis Research Society 22-question Questionnaire [SRS-22], 36-Item Short Form Health Survey [SF-36], visual analog scale [VAS] for back/leg pain) from each group were assessed and compared with each other using ANOVA. 29087808 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE Demographics, alignment, and SRS-Schwab modifiers were assessed with χ/paired t tests to compare HRQLs: Scoliosis Research Society 22-question Questionnaire (SRS-22), Numeric Rating Scale (NRS) Back/Leg Pain, Oswestry Disability Index (ODI). 31651683 2020
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.010 Biomarker phenotype BEFREE Multimodality imaging, including MRI, bone scintigraphy, and FDG PET/CT, was performed to evaluate a 49-year-old man who had right hip and lower limb pain for 4 months because possible malignancy was suspected. 28639953 2017
Entrez Id: 6687
Gene Symbol: SPG7
SPG7
0.100 Biomarker phenotype HPO
Entrez Id: 6690
Gene Symbol: SPINK1
SPINK1
0.010 Biomarker phenotype BEFREE At 24 months there was no significant difference between clinical outcomes of the β-TCP or rhBMP-2 patients, with improvements in back pain (46% and 49%; P = 0.98), leg pain (31 and 52%; P = 0.14), ODI (38 and 41%; P = 0.81), SF-36 PCS (37 and 38%; P = 0.87), and SF-36 MCS (8 and 8%; P = 0.93). 28028645 2017
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Clinical outcomes were assessed using numeric rating scale for back and radiating leg pain (NRS back and leg), Oswestry Disability Index (ODI), and modified MacNab criteria at 1 month (short-term follow-up) and at least 12 months (long-term follow-up) after PELD. 29292235 2018
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 Biomarker phenotype BEFREE While tonic stimulation reduced leg pain (p < 0.05), the burst mode added an extra pain reduction (ΔNRS 1.2 ± 1.5) (p < 0.01). 30328646 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 Biomarker phenotype BEFREE Thirteen FCs were decompressed (no adverse events) NRS leg pain and ODI improved from 6.85 ± 0.69 and 65.08 ± 7.95 preoperatively to 1 ± 0.91 and 13.46 ± 5.19 at 1-yr follow-up, respectively. 31550357 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Similar results could be observed for the long-term follow-up subgroup (50%, <i>n</i> = 33) with significantly less back pain (NRS 3.94 versus 7.0; <i>p</i> < 0.0001) and leg pain (visual analog scale 3.14 versus 5.39; <i>p</i> < 0.002) postoperatively. 30517963 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Outcomes measured included the Oswestry Disability Index (ODI), NRS scales for back and leg pain (NRS-B/NRS-L), CSORN questions pertaining to patient satisfaction with surgery and whether or not the surgery met expectations. 30471460 2019
Entrez Id: 412
Gene Symbol: STS
STS
0.020 Biomarker phenotype BEFREE The 5R-STS test showed no correlation with VAS for leg pain and EQ-5D VAS (p > 0.05). 29957147 2018
Entrez Id: 412
Gene Symbol: STS
STS
0.020 GeneticVariation phenotype BEFREE The association of MBP and MLP with 5R-STS test times as well as with the presence of OFI (> 10.5 s) and severe OFI (> 22.0 s) as determined by the 5R-STS baseline severity stratification was quantified by use of crude and adjusted regression models.A total of 258 patients were included. 31451936 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker phenotype HPO