Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.010 GeneticVariation phenotype BEFREE Gait disturbance and lower limb pain in a patient with PIK3CA-related disorder. 28867506 2017
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE Perioperative spinal deformity parameters, complications, and HRQoL outcome scores (Oswestry Disability Index [ODI], Scoliosis Research Society 22-question Questionnaire [SRS-22], 36-Item Short Form Health Survey [SF-36], visual analog scale [VAS] for back/leg pain) from each group were assessed and compared with each other using ANOVA. 29087808 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE Perioperative spinal deformity parameters, complications, and HRQoL outcome scores (Oswestry Disability Index [ODI], Scoliosis Research Society 22-question Questionnaire [SRS-22], 36-Item Short Form Health Survey [SF-36], visual analog scale [VAS] for back/leg pain) from each group were assessed and compared with each other using ANOVA. 29087808 2018
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Clinical outcomes were assessed using numeric rating scale for back and radiating leg pain (NRS back and leg), Oswestry Disability Index (ODI), and modified MacNab criteria at 1 month (short-term follow-up) and at least 12 months (long-term follow-up) after PELD. 29292235 2018
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Clinical outcomes were assessed using numeric rating scale for back and radiating leg pain (NRS back and leg), Oswestry Disability Index (ODI), and modified MacNab criteria at 1 month (short-term follow-up) and at least 12 months (long-term follow-up) after PELD. 29292235 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 412
Gene Symbol: STS
STS
0.020 Biomarker phenotype BEFREE The 5R-STS test showed no correlation with VAS for leg pain and EQ-5D VAS (p > 0.05). 29957147 2018
Entrez Id: 282991
Gene Symbol: BLOC1S2
BLOC1S2
0.010 Biomarker phenotype BEFREE In an international, randomized, double-blind, parallel-group study, patients classified C0s to C4 according to Clinical Etiological Anatomic Pathophysiologic [CEAP] classification and with leg pain graded as superior to 4 cm on a 10-cm visual analog scale (VAS), were treated for 8 weeks with either MPFF 1000 mg once daily or MPFF 500 mg twice daily. 29992831 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 AlteredExpression phenotype BEFREE Acute exercise in children with JIA induced slightly musculoskeletal leg pain and transient increased plasma calprotectin levels but not IL-6 levels. 30008613 2018
Entrez Id: 268
Gene Symbol: AMH
AMH
0.010 Biomarker phenotype BEFREE Patients undergoing MIS LD demonstrated significant improvements in PROMIS PF, ODI, VAS back, and VAS leg pain postoperatively. 30095799 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 Biomarker phenotype BEFREE While tonic stimulation reduced leg pain (p < 0.05), the burst mode added an extra pain reduction (ΔNRS 1.2 ± 1.5) (p < 0.01). 30328646 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 Biomarker phenotype BEFREE While tonic stimulation reduced leg pain (p < 0.05), the burst mode added an extra pain reduction (ΔNRS 1.2 ± 1.5) (p < 0.01). 30328646 2019
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.030 Biomarker phenotype BEFREE High-frequency spinal cord stimulation at 10 kHz (HF10-SCS) has been demonstrated to provide enhanced and durable pain relief in patients with chronic back and radiating leg pain. 30365222 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Outcomes measured included the Oswestry Disability Index (ODI), NRS scales for back and leg pain (NRS-B/NRS-L), CSORN questions pertaining to patient satisfaction with surgery and whether or not the surgery met expectations. 30471460 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Outcomes measured included the Oswestry Disability Index (ODI), NRS scales for back and leg pain (NRS-B/NRS-L), CSORN questions pertaining to patient satisfaction with surgery and whether or not the surgery met expectations. 30471460 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Similar results could be observed for the long-term follow-up subgroup (50%, <i>n</i> = 33) with significantly less back pain (NRS 3.94 versus 7.0; <i>p</i> < 0.0001) and leg pain (visual analog scale 3.14 versus 5.39; <i>p</i> < 0.002) postoperatively. 30517963 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Similar results could be observed for the long-term follow-up subgroup (50%, <i>n</i> = 33) with significantly less back pain (NRS 3.94 versus 7.0; <i>p</i> < 0.0001) and leg pain (visual analog scale 3.14 versus 5.39; <i>p</i> < 0.002) postoperatively. 30517963 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 Biomarker phenotype BEFREE In this cohort, no significant differences in serum levels of TNFα, IL-6 or any other biomarkers were seen between patients with sciatica and those with back pain with referred leg pain. 31077179 2019
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.010 GeneticVariation phenotype BEFREE Patient-reported back and leg pain using the visual analog scale (VAS) and opioid dose (milligrams morphine equivalent/day, MME/day) were compared at 12 months post-10 kHz SCS therapy to baseline. 31391503 2019
Entrez Id: 4311
Gene Symbol: MME
MME
0.010 Biomarker phenotype BEFREE Patient-reported back and leg pain using the visual analog scale (VAS) and opioid dose (milligrams morphine equivalent/day, MME/day) were compared at 12 months post-10 kHz SCS therapy to baseline. 31391503 2019
Entrez Id: 412
Gene Symbol: STS
STS
0.020 GeneticVariation phenotype BEFREE The association of MBP and MLP with 5R-STS test times as well as with the presence of OFI (> 10.5 s) and severe OFI (> 22.0 s) as determined by the 5R-STS baseline severity stratification was quantified by use of crude and adjusted regression models.A total of 258 patients were included. 31451936 2019
Entrez Id: 3929
Gene Symbol: LBP
LBP
0.020 Biomarker phenotype BEFREE Decompression surgery can improve low back pain, regardless of the degree of preoperative leg pain, but the average score for LBP and leg pain slightly worsened between 3 months and 1 year after surgery. 31473813 2020
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 Biomarker phenotype BEFREE Thirteen FCs were decompressed (no adverse events) NRS leg pain and ODI improved from 6.85 ± 0.69 and 65.08 ± 7.95 preoperatively to 1 ± 0.91 and 13.46 ± 5.19 at 1-yr follow-up, respectively. 31550357 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 Biomarker phenotype BEFREE Thirteen FCs were decompressed (no adverse events) NRS leg pain and ODI improved from 6.85 ± 0.69 and 65.08 ± 7.95 preoperatively to 1 ± 0.91 and 13.46 ± 5.19 at 1-yr follow-up, respectively. 31550357 2019