Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 140821
Gene Symbol: RSS
RSS
0.030 Biomarker phenotype BEFREE HRQOL questionnaires included the Oswestry Disability Index (ODI), Scoliosis Research Society (SRS-22r), 36-item Short-Form Health Survey, and numeric rating scale (NRS) for back and leg pain. 29570046 2018
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 55034
Gene Symbol: MOCOS
MOCOS
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 4184
Gene Symbol: SMCP
SMCP
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.030 Biomarker phenotype BEFREE Patients with both back and leg pain already implanted with an HF10 therapy device for up to 24 months were included in this multicenter study. 28535555 2017
Entrez Id: 55034
Gene Symbol: MOCOS
MOCOS
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.030 Biomarker phenotype BEFREE Recent FDA approval and superiority of the Nevro Senza 10-kHz high frequency (HF10) spinal cord stimulation (SCS) therapy over traditional low-frequency spinal cord stimulation for treatment of chronic back and leg pain may provide a new interventional therapeutic option for patients suffering from CRPS. 28072810 2017
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.030 GeneticVariation phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 55906
Gene Symbol: ZC4H2
ZC4H2
0.030 GeneticVariation phenotype BEFREE Preoperatively to 12-month follow-up there were increases in segmental lordosis (7.9-9.4 degrees, P=0.0497), lumbar lordosis (48.8-55.2 degrees, P=0.0328), and disk height (3.7-5.5 mm, P=0.0018); there were also improvements in back (58.6%) and leg pain (60.0%), ODI (44.4%), PCS (56.7%), and MCS (16.1%) for stand-alone XLIF. 28207620 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.030 GeneticVariation phenotype BEFREE An interaction between the IL6 haplotype and physical work load was significant for the duration of back and leg pain and sick leave (p=0.038, 0.011 and 0.006, respectively). 18321738 2008
Entrez Id: 5067
Gene Symbol: CNTN3
CNTN3
0.040 Biomarker phenotype BEFREE PROMs analyzed were the Short Form-12 Physical Component Score (PCS-12), Mental Component Score (MCS-12), Oswestry Disability Index (ODI), and Visual Analog Scale (VAS) Back and Leg pain scores. 31770335 2020
Entrez Id: 5067
Gene Symbol: CNTN3
CNTN3
0.040 Biomarker phenotype BEFREE There was no significant difference in proportion that achieved minimal clinically important difference for ODI, PCS, BP, and LP (P>0.05). 31714282 2019
Entrez Id: 5067
Gene Symbol: CNTN3
CNTN3
0.040 Biomarker phenotype BEFREE Clinical outcome measures included back and leg pain (visual analogue scale), Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28207620 2017
Entrez Id: 5067
Gene Symbol: CNTN3
CNTN3
0.040 Biomarker phenotype BEFREE Clinical outcomes included back and leg pain, Oswestry Disability Index (ODI), and SF-36 physical and mental component scores (PCS and MCS). 28028645 2017
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 Biomarker phenotype BEFREE While tonic stimulation reduced leg pain (p < 0.05), the burst mode added an extra pain reduction (ΔNRS 1.2 ± 1.5) (p < 0.01). 30328646 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 Biomarker phenotype BEFREE Thirteen FCs were decompressed (no adverse events) NRS leg pain and ODI improved from 6.85 ± 0.69 and 65.08 ± 7.95 preoperatively to 1 ± 0.91 and 13.46 ± 5.19 at 1-yr follow-up, respectively. 31550357 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 Biomarker phenotype BEFREE Thirteen FCs were decompressed (no adverse events) NRS leg pain and ODI improved from 6.85 ± 0.69 and 65.08 ± 7.95 preoperatively to 1 ± 0.91 and 13.46 ± 5.19 at 1-yr follow-up, respectively. 31550357 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Similar results could be observed for the long-term follow-up subgroup (50%, <i>n</i> = 33) with significantly less back pain (NRS 3.94 versus 7.0; <i>p</i> < 0.0001) and leg pain (visual analog scale 3.14 versus 5.39; <i>p</i> < 0.002) postoperatively. 30517963 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Similar results could be observed for the long-term follow-up subgroup (50%, <i>n</i> = 33) with significantly less back pain (NRS 3.94 versus 7.0; <i>p</i> < 0.0001) and leg pain (visual analog scale 3.14 versus 5.39; <i>p</i> < 0.002) postoperatively. 30517963 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Outcomes measured included the Oswestry Disability Index (ODI), NRS scales for back and leg pain (NRS-B/NRS-L), CSORN questions pertaining to patient satisfaction with surgery and whether or not the surgery met expectations. 30471460 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 Biomarker phenotype BEFREE While tonic stimulation reduced leg pain (p < 0.05), the burst mode added an extra pain reduction (ΔNRS 1.2 ± 1.5) (p < 0.01). 30328646 2019
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Outcomes measured included the Oswestry Disability Index (ODI), NRS scales for back and leg pain (NRS-B/NRS-L), CSORN questions pertaining to patient satisfaction with surgery and whether or not the surgery met expectations. 30471460 2019
Entrez Id: 4677
Gene Symbol: NARS1
NARS1
0.050 GeneticVariation phenotype BEFREE Clinical outcomes were assessed using numeric rating scale for back and radiating leg pain (NRS back and leg), Oswestry Disability Index (ODI), and modified MacNab criteria at 1 month (short-term follow-up) and at least 12 months (long-term follow-up) after PELD. 29292235 2018
Entrez Id: 83985
Gene Symbol: SPNS1
SPNS1
0.050 GeneticVariation phenotype BEFREE Clinical outcomes were assessed using numeric rating scale for back and radiating leg pain (NRS back and leg), Oswestry Disability Index (ODI), and modified MacNab criteria at 1 month (short-term follow-up) and at least 12 months (long-term follow-up) after PELD. 29292235 2018
Entrez Id: 5251
Gene Symbol: PHEX
PHEX
0.100 CausalMutation phenotype CLINVAR