Gene: FLT3 ×
Source: INFERRED ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. 15374878 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. 16410449 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Continuing aspirin in the perioperative patient. 22504186 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 Biomarker disease HPO
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184 2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia. 15625552 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. 23714533 2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. 17889720 2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia. 15863200 2005
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 GeneticVariation disease CLINVAR Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient. 16371029 2006
Entrez Id: 2322
Gene Symbol: FLT3
FLT3 		1.000 CausalMutation disease CLINVAR Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. 24046014 2013