Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2
0.010 AlteredExpression disease BEFREE In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38. 31547619 2019
Entrez Id: 7864
Gene Symbol: SCLC1
SCLC1
0.010 Biomarker disease BEFREE Some of the identified triggering factors include: viruses, especially herpes simplex, accounting for the majority of relapses occurring after viral encephalitis, which respond to immunotherapy rather than antiviral agents; tumors especially teratoma, SCLC and thymomas; and biological cancer therapies (immune-check-point inhibitors). 31611142 2019
Entrez Id: 8718
Gene Symbol: TNFRSF25
TNFRSF25
0.010 AlteredExpression disease BEFREE Real-time PCR analysis confirmed that CCL25 was upregulated; and MYC, GADD45B, TNFRSF12 downregulated in thymoma with MG. Our study thus provided important genetic information on thymoma. 30787364 2019
Entrez Id: 2056
Gene Symbol: EPO
EPO
0.010 Biomarker disease BEFREE Occurrence of acute pulmonary embolism induced by recombinant erythropoietin during treatment of pure red cell aplasia associated with thymoma: A case report. 30855492 2019
Entrez Id: 1211
Gene Symbol: CLTA
CLTA
0.010 Biomarker disease BEFREE These findings demonstrate a disparate role of RP11-424C20.2/UHRF1 axis in LIHC and THYM via regulating immune infiltrates, and also indicate a therapeutic value for UHRF1 inhibitors in combination with anti-PD-L1/CLTA-4 blockade. 31442209 2019
Entrez Id: 4616
Gene Symbol: GADD45B
GADD45B
0.010 AlteredExpression disease BEFREE Real-time PCR analysis confirmed that CCL25 was upregulated; and MYC, GADD45B, TNFRSF12 downregulated in thymoma with MG. Our study thus provided important genetic information on thymoma. 30787364 2019
Entrez Id: 10580
Gene Symbol: SORBS1
SORBS1
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 998
Gene Symbol: CDC42
CDC42
0.010 AlteredExpression disease BEFREE CDC42 was significantly down-regulated in type B2 thymomas compared with other subtypes. 29645059 2018
Entrez Id: 10487
Gene Symbol: CAP1
CAP1
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 23476
Gene Symbol: BRD4
BRD4
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 9557
Gene Symbol: CHD1L
CHD1L
0.010 AlteredExpression disease BEFREE CHD1L was up-regulated in type AB and type B thymomas compared with type A thymoma. 29645059 2018
Entrez Id: 1483
Gene Symbol: CTAA1
CTAA1
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
0.010 Biomarker disease BEFREE Further <i>in vitro</i> studies, we demonstrated for the first time that D-dencichine significantly stimulated megakaryocyte adhesion, migration, and proplatelet formation in a dose-dependent manner through extracellular regulated protein kinases1/2 (ERK1/2) and v-akt murine thymoma viral oncogene homolog (AKT) signaling pathways. 29666579 2018
Entrez Id: 4012
Gene Symbol: LNPEP
LNPEP
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 10000
Gene Symbol: AKT3
AKT3
0.010 Biomarker disease BEFREE The insulin signaling pathway was further analyzed for its close connections to Wnt and MAPK signaling pathways as well as for the containing of thymoma viral proto-oncogene-3 (Akt3) and glycogen synthase kinase-3 beta (Gsk3b), which were both target genes predicted by most DE miRNA. 29766503 2018
Entrez Id: 5376
Gene Symbol: PMP22
PMP22
0.010 Biomarker disease BEFREE One (2.9%) patient with CIDP and thymoma had CASPR2 antibodies. 29761119 2018
Entrez Id: 2539
Gene Symbol: G6PD
G6PD
0.010 Biomarker disease BEFREE The present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µM) during IVM on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (SOD2), glutathione peroxidase 1 (GPX1), catalase (CAT)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (TP53), caspase 3, apoptosis-related cysteine protease (CASP3)), cell cycle progression (cellular cycle V-Akt murine thymoma viral oncogene homologue 1 (AKT1)), cumulus expansion (gap junction protein, alpha 1, 43 kDa (GJA1) and prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclo-oxygenase) (PTGS2)) and metabolism (glucose-6-phosphate dehydrogenase (G6PD)). 29966585 2018
Entrez Id: 847
Gene Symbol: CAT
CAT
0.010 Biomarker disease BEFREE The present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µM) during IVM on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (SOD2), glutathione peroxidase 1 (GPX1), catalase (CAT)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (TP53), caspase 3, apoptosis-related cysteine protease (CASP3)), cell cycle progression (cellular cycle V-Akt murine thymoma viral oncogene homologue 1 (AKT1)), cumulus expansion (gap junction protein, alpha 1, 43 kDa (GJA1) and prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclo-oxygenase) (PTGS2)) and metabolism (glucose-6-phosphate dehydrogenase (G6PD)). 29966585 2018
Entrez Id: 2876
Gene Symbol: GPX1
GPX1
0.010 Biomarker disease BEFREE The present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µM) during IVM on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (SOD2), glutathione peroxidase 1 (GPX1), catalase (CAT)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (TP53), caspase 3, apoptosis-related cysteine protease (CASP3)), cell cycle progression (cellular cycle V-Akt murine thymoma viral oncogene homologue 1 (AKT1)), cumulus expansion (gap junction protein, alpha 1, 43 kDa (GJA1) and prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclo-oxygenase) (PTGS2)) and metabolism (glucose-6-phosphate dehydrogenase (G6PD)). 29966585 2018
Entrez Id: 5269
Gene Symbol: SERPINB6
SERPINB6
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 10296
Gene Symbol: MAEA
MAEA
0.010 AlteredExpression disease BEFREE Previous studies have also demonstrated that downregulation of Emp affects the expression of mitogen-associated protein kinase 1 (MAPK1) and thymoma viral protooncogene (AKT-1) resulting in abnormal cell motility. 29032607 2018
Entrez Id: 9200
Gene Symbol: HACD1
HACD1
0.010 Biomarker disease BEFREE Based on available data, the most popular and active regimens are cisplatin-anthracycline (CAP or ADOC) or cisplatin-etoposide combinations that should be recommended when considering first-line chemotherapy in thymoma or thymic carcinoma. 30527189 2018
Entrez Id: 8140
Gene Symbol: SLC7A5
SLC7A5
0.010 Biomarker disease BEFREE We thus found that LAT1 immunoreactivity was undetectable in all of the thymoma specimens, regardless of the subtypes of thymoma. 30449824 2018
Entrez Id: 2017
Gene Symbol: CTTN
CTTN
0.010 Biomarker disease BEFREE Autoantibodies against intracellular targets, namely cortactin, titin, and ryanodine receptor (the latter two being associated with the presence of thymoma), may also be helpful as biomarkers in some patients. 29377162 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.010 Biomarker disease BEFREE SMAD4 may play a specific role in tumorigenesis and the development of aA thymomas and thymic carcinomas. 29645059 2018