Self-Reported Mild Traumatic Brain Injuries in Relation to Rumination and Depressive Symptoms: Moderating Role of Sex Differences and a Brain-Derived Neurotrophic Factor Gene Polymorphism.
Self-Reported Mild Traumatic Brain Injuries in Relation to Rumination and Depressive Symptoms: Moderating Role of Sex Differences and a Brain-Derived Neurotrophic Factor Gene Polymorphism.
In the population study, BDNF-rs6265 and CREB1-rs2253206 major alleles were significantly associated with rumination and through rumination with current depression severity.
The BDNFVal66Met polymorphism was examined in DNA samples from the mothers and daughters, and measures of depressive symptoms and rumination were also obtained.
A total of 827 healthy young male and female college students (aged 21·3 (sd 3·0) years; BMI 16-41·7 kg/m2) were genotyped for the 5-HTTLPR polymorphism and assessed for rumination (Event Related Ruminative Index) and body weight.
The present study examined the interaction between early life stress and 5-HTT genotypes in predicting two risk factors for suicidal behavior - the brooding subtype of rumination and impulsivity, in the form of negative urgency - over time.
All but one item of the PCL-C are predicted by intrusive rumination, while the variance of only 4 items of the PTGI are explained by deliberate rumination.
All but one item of the PCL-C are predicted by intrusive rumination, while the variance of only 4 items of the PTGI are explained by deliberate rumination.
In the population study, BDNF-rs6265 and CREB1-rs2253206 major alleles were significantly associated with rumination and through rumination with current depression severity.
Since rumination involves memory, we tested the hypothesis that variation in the genes encoding GIRK2 (KCNJ6) and CREB1 mechanisms would influence RRS scores.
The aim of the present study was to establish whether in people struggling with cancer there is an association between the degree of PTG and the level of deliberate and intrusive ruminations, occurring soon after the diagnosis of disease and currently, and whether deliberate ruminations play a mediating role between intrusive ruminations and PTG.
The aim of the present study was to establish whether in people struggling with cancer there is an association between the degree of PTG and the level of deliberate and intrusive ruminations, occurring soon after the diagnosis of disease and currently, and whether deliberate ruminations play a mediating role between intrusive ruminations and PTG.
Study 2, performed on an internet-based sample (N = 602), explored relations of the CAS-1 with measures of rumination, psychopathology, and quality of life.
While no genome-wide significant hit emerged at the SNP level, the association of rumination survived correction for multiple testing with KCTD12 at the gene level, and with the set of genes binding miR-383 at the gene set level.
We revealed two significant models: both the association of methylation site rs6311 with rumination and that of miRNA binding site rs3125 (supposed to bind miR-1270, miR-1304, miR-202, miR-539 and miR-620) with brooding were a function of childhood adversity, and both interaction findings were significantly present both in the never-depressed and in the ever-depressed group.
Study 2, performed on an internet-based sample (N = 602), explored relations of the CAS-1 with measures of rumination, psychopathology, and quality of life.