Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.040 GeneticVariation BEFREE In the population study, BDNF-rs6265 and CREB1-rs2253206 major alleles were significantly associated with rumination and through rumination with current depression severity. 21215389

2011
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.040 GeneticVariation BEFREE These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination. 21745335

2011
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.040 GeneticVariation BEFREE The BDNF Val66Met polymorphism is associated with rumination in healthy adults. 19653783

2009
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.040 GeneticVariation BEFREE Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression. 17959306

2007
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination. 21745335

2011
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE The BDNF Val66Met polymorphism is associated with rumination in healthy adults. 19653783

2009
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.030 GeneticVariation BEFREE Rumination may be an endophenotype in the pathway from the BDNF Val66Met polymorphism to depression. 17959306

2007
dbSNP: rs3125
rs3125
HTR2A
0.010 GeneticVariation BEFREE We revealed two significant models: both the association of methylation site rs6311 with rumination and that of miRNA binding site rs3125 (supposed to bind miR-1270, miR-1304, miR-202, miR-539 and miR-620) with brooding were a function of childhood adversity, and both interaction findings were significantly present both in the never-depressed and in the ever-depressed group. 31258491

2019
dbSNP: rs6311
rs6311
HTR2A
0.010 GeneticVariation BEFREE We revealed two significant models: both the association of methylation site rs6311 with rumination and that of miRNA binding site rs3125 (supposed to bind miR-1270, miR-1304, miR-202, miR-539 and miR-620) with brooding were a function of childhood adversity, and both interaction findings were significantly present both in the never-depressed and in the ever-depressed group. 31258491

2019
dbSNP: rs1360780
rs1360780
FKBP5 ; LOC112267956
0.010 GeneticVariation BEFREE We hypothesized that adolescent carriers of the FKBP5 CATT haplotype composed of rs9296158, rs3800373, rs1360780, and rs9470080, that has been associated with increased risk for psychiatric disorders in adulthood, would also show higher levels of rumination and catastrophizing. 28654774

2017
dbSNP: rs9470080
rs9470080
FKBP5
0.010 GeneticVariation BEFREE We hypothesized that adolescent carriers of the FKBP5 CATT haplotype composed of rs9296158, rs3800373, rs1360780, and rs9470080, that has been associated with increased risk for psychiatric disorders in adulthood, would also show higher levels of rumination and catastrophizing. 28654774

2017
dbSNP: rs11754661
rs11754661
MTHFD1L
0.010 GeneticVariation BEFREE However, the A allele of MTHFD1L rs11754661 was significantly associated with greater rumination, and this effect was replicated in both the Budapest and Manchester samples. 26926881

2016
dbSNP: rs1217691063
rs1217691063
MTHFR
0.010 GeneticVariation BEFREE In the present study, we explored the association of rumination (measured by the Ruminative Responses Scale) with polymorphisms of two distinct folate pathway genes, MTHFR rs1801133 (C677T) and MTHFD1L rs11754661, in a combined European white sample from Budapest, Hungary (n=895) and Manchester, United Kingdom (n=1309). 26926881

2016
dbSNP: rs1339039642
rs1339039642
MTHFD1L
0.010 GeneticVariation BEFREE In the present study, we explored the association of rumination (measured by the Ruminative Responses Scale) with polymorphisms of two distinct folate pathway genes, MTHFR rs1801133 (C677T) and MTHFD1L rs11754661, in a combined European white sample from Budapest, Hungary (n=895) and Manchester, United Kingdom (n=1309). 26926881

2016
dbSNP: rs1801133
rs1801133
MTHFR
0.010 GeneticVariation BEFREE Despite its functional effect on folate metabolism, the MTHFR rs1801133 showed no effect on rumination. 26926881

2016
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.010 GeneticVariation BEFREE We predicted that COMT Val158Met genotype, which has been linked to heightened amygdala reactivity and deficits in prefrontal functioning, would be associated with brooding rumination and HRV, particularly among women with a history of past MDD. 24661160

2014
dbSNP: rs6277
rs6277
DRD2
0.010 GeneticVariation BEFREE Given these associations, we examined in the present study whether depressive rumination is related to the C957T polymorphism in 317 clinically depressed individuals and 317 never-depressed control individuals. 22864973

2012
dbSNP: rs2253206
rs2253206 		0.010 GeneticVariation BEFREE In the population study, BDNF-rs6265 and CREB1-rs2253206 major alleles were significantly associated with rumination and through rumination with current depression severity. 21215389

2011