Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 GeneticVariation phenotype BEFREE The sensitivities to burning pain and capsaicin of Japanese adult subjects were compared with their TRPV1 genome sequence, and we detected 6 single-nucleotide polymorphisms and 11 single-nucleotide polymorphisms related to burning pain and capsaicin sensitivity, respectively. 30209980 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 AlteredExpression phenotype BEFREE When expressed by sensory neurons, activation of TRPV1 channels by heat (>40 °C), capsaicin (sub-micromolar), or acid environment (pH < 6), causes depolarization leading to burning pain sensation in mammals. 31026506 2019
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype BEFREE Capsaicin is an ingredient in spicy peppers that produces burning pain by activating transient receptor potential vanilloid 1 (TRPV1), a Ca<sup>2+</sup>-permeable ion channel in nociceptors. 28360106 2017
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype BEFREE Such polymodal-sensor aspect makes the TRPV1 channel extremely versatile and important for its role in sensing burning pain. 27038373 2016
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Biomarker phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.340 Therapeutic phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Antinociceptive activity of Riparin II from Aniba riparia: Further elucidation of the possible mechanisms. 29655911 2018
Entrez Id: 4879
Gene Symbol: NPPB
NPPB 		0.300 Therapeutic phenotype CTD_human Brain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats. 27687165 2016
Entrez Id: 4881
Gene Symbol: NPR1
NPR1 		0.300 Therapeutic phenotype CTD_human Brain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats. 27687165 2016
Entrez Id: 3082
Gene Symbol: HGF
HGF 		0.300 Therapeutic phenotype CTD_human Double-blind, placebo-controlled study of HGF gene therapy in diabetic neuropathy. 26000320 2015
Entrez Id: 3231
Gene Symbol: HOXD1
HOXD1 		0.300 Biomarker phenotype CTD_human An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. 21151121 2011
Entrez Id: 3827
Gene Symbol: KNG1
KNG1 		0.300 Biomarker phenotype CTD_human Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. 20018876 2010
Entrez Id: 623
Gene Symbol: BDKRB1
BDKRB1 		0.300 Biomarker phenotype CTD_human Kinin B1 receptors contributes to acute pain following minor surgery in humans. 20152050 2010
Entrez Id: 5173
Gene Symbol: PDYN
PDYN 		0.300 Biomarker phenotype CTD_human Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli. 20068450 2010
Entrez Id: 5443
Gene Symbol: POMC
POMC 		0.300 Biomarker phenotype CTD_human Serum beta-endorphin response to stress before and after operation under fentanyl anesthesia in neonates, infants and preschool children. 20084599 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker phenotype CTD_human Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 20383154 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1 		0.300 Biomarker phenotype CTD_human Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. 20561508 2010
Entrez Id: 4923
Gene Symbol: NTSR1
NTSR1 		0.300 Therapeutic phenotype CTD_human Altered morphine-induced analgesia in neurotensin type 1 receptor null mice. 20727387 2010
Entrez Id: 3084
Gene Symbol: NRG1
NRG1 		0.300 Biomarker phenotype CTD_human Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. 20561508 2010