Gene: SDHB ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Familial paragangliomas: case report and literature review. 18753105 2009
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE All nine pediatric/adolescent GISTs and seven adult wild-type GISTs were negative for SDHB immunohistochemistry. 23174939 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR [Intrapericardical paraganglioma associated with mutation in succinate dehydrogenase enzyme gene]. 24939699 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR A comprehensive next generation sequencing-based genetic testing strategy to improve diagnosis of inherited pheochromocytoma and paraganglioma. 23666964 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing. 16912137 2006
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Novel germline mutations in the SDHB and SDHD genes in Japanese pheochromocytomas. 17308434 2007
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma. 20592014 2010
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Pheochromocytoma and paraganglioma syndromes: genetics and management update. 24523625 2014
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE Succinate dehydrogenase-deficient gastrointestinal stromal tumors (SDH-deficient GISTs) are a unique class of GIST defined by negative immunohistochemical staining for succinate dehydrogenase B (SDHB). 23060355 2013
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum. 26259135 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group BEFREE The great majority of GISTs harbour mutually exclusive activating mutations in genes coding for the type III receptor tyrosine kinases KIT and PDGFRA; less commonly, GISTs have also been reported to display mutations elsewhere, including BRAF and NF1 and SDH-complex genes. 27943096 2017
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Screening of mutations in genes that predispose to hereditary paragangliomas and pheochromocytomas. 22517554 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice. 25695889 2015
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Genetic testing in pheochromocytoma or functional paraganglioma. 16314641 2005
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function. 22835832 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Phenotype of SDHB mutation carriers in the Netherlands. 25047027 2014
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group GENOMICS_ENGLAND Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes. 27604308 2016
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 GeneticVariation group CLINVAR Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer. 23083876 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE All GISTs from patients with Carney-Stratakis syndrome and Carney triad were negative for SDHB immunohistochemically. 20890271 2011
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR High prevalence of founder mutations of the succinate dehydrogenase genes in the Netherlands. 21348866 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Malignant paraganglioma associated with succinate dehydrogenase subunit B in an 8-year-old child: the age of first screening? 19189136 2009
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. 11404820 2001
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group GENOMICS_ENGLAND Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency. 22972948 2012
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 CausalMutation group CLINVAR Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas. 17200167 2007
Entrez Id: 6390
Gene Symbol: SDHB
SDHB 		0.800 Biomarker group BEFREE Immunohistochemically, the GISTs are CD117, DOG-1 positive, SDHA negative (if SDHA mutated), SDHA positive (if SDHA intact) and SDHB negative. 27317811 2016