Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. 28724667 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.800 CausalMutation disease CLINVAR Germline BRCA2 mutations detected in pediatric sequencing studies impact parents' evaluation and care. 28655807 2018
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks. 28779002 2018
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 GeneticVariation disease CLINVAR Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic. 27106063 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50. 28678401 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer. 27783279 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Frequency of germline PALB2 mutations among women with epithelial ovarian cancer. 27631815 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Do founder mutations characteristic of some cancer sites also predispose to pancreatic cancer? 27038244 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results. 28008555 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic. 27106063 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 GeneticVariation disease CLINVAR Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria. 28492532 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR This study was performed to evaluate the frequency of mutations in CHEK2, PALB2, MRE11, and RAD50 among Korean patients at high risk for hereditary breast cancer. 27783279 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer. 27153395 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 GeneticVariation disease UNIPROT Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. 28319063 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Pathogenic variants in CHEK2, PALB2, MRE11, and RAD50 were detected in a small proportion of Korean patients with features of hereditary breast cancer. 27783279 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 Biomarker disease CLINGEN Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. 28319063 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. 26640152 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Identification of germline alterations in breast cancer predisposition genes among Malaysian breast cancer patients using panel testing. 26757417 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 GeneticVariation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.800 Biomarker disease BEFREE Prospective cohort study of 6036 BRCA1 and 3820 BRCA2 female carriers (5046 unaffected and 4810 with breast or ovarian cancer or both at baseline) recruited in 1997-2011 through the International BRCA1/2 Carrier Cohort Study, the Breast Cancer Family Registry and the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, with ascertainment through family clinics (94%) and population-based studies (6%). 28632866 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Improving performance of multigene panels for genomic analysis of cancer predisposition. 26845104 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria. 28492532 2017
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 CausalMutation disease CLINVAR Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy. 26296701 2016
Entrez Id: 79728
Gene Symbol: PALB2
PALB2 		0.800 GeneticVariation disease CLINVAR Mutations in PALB2 are less common than BRCA1 and BRCA2 in familial breast cancer patients. 25794774 2016