Prediabetes is associated with genetic variations in the gene encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channel (KCNJ11): A case-control study in a Han Chinese youth population.
We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and prediabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11.
The KCNJ11E23K variant was associated with the progression to prediabetes after a median interval of 12 years on multinomial logistic regression analysis, even after adjustment for traditional risk factors (OR 1.29, P(age, sex, BMI and fasting plasma glucose [FPG] adjusted) = 0.02).
Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats.
After the adjustment for possible covariates, the A allele of rs1800849 in UCP3 was significantly associated with prediabetes (aOR<sub>AA vs GG</sub> = 1.68, 95% CI: 1.02-2.78), and the association was also significant under the recessive model (aOR <sub>AA vs GA + GG</sub> = 1.64, 95% CI: 1.02-2.66).
Using a high-energy-diet induced pre-diabetic rat model, we evaluated testicular levels of PGC-1α and its downstream targets, nuclear respiratory factors 1 (NRF-1) and 2 (NRF-2), mitochondrial transcription factor A (TFAM) and Sirt3.
Using a high-energy-diet induced pre-diabetic rat model, we evaluated testicular levels of PGC-1α and its downstream targets, nuclear respiratory factors 1 (NRF-1) and 2 (NRF-2), mitochondrial transcription factor A (TFAM) and Sirt3.
Prediabetes<sub>IEC</sub> was diagnosed by "HbA<sub>1c</sub> 42-46 mmol/mol and/or FPG 6.1-6.9 mmol/L", Prediabetes<sub>ADA</sub> by "HbA<sub>1c</sub> 39-46 mmol/mol and/or FPG 5.6-6.9 mmol/L", Prediabetes<sub>ADA-IEC</sub> for the condition met the ADA but not the IEC prediabetes definition, and the ADA-normal glucose regulation (NGR<sub>ADA</sub>) by both HbA<sub>1c</sub> and FPG lower than Prediabetes<sub>ADA</sub>.
Using ADA 2011 glycaemic categories, 33% (n = 693) of cohort 1 (prediabetes risk) had normal glucose regulation and 67% (n = 1419) had impaired glucose regulation.