|
rs5219
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results confirm that the common E23K polymorphism of KCNJ11 carries a higher susceptibility to the development of prediabetes in the Chinese Han population.
|
28449408 |
2018 |
|
rs7903146
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs7903146 Variant in the <i>TCF7L2</i> Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.
|
28611053 |
2017 |
|
rs7903146
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This cross-sectional study aimed to investigate the independent risk factors for prediabetes, considering the contribution of genetic factors (TCF7L2-rs7903146, IRS1-rs1801278, INSR-rs3745551, CDKN2A-rs10811661, and FTO-rs9939609), socio-economic status, and lifestyle factors.
|
26334876 |
2015 |
|
rs5219
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study has provided supporting evidence for the role of the E23K variant in glycaemic progression in Chinese, with its effect being more evident in the early stage of T2DM, as the subjects progressed from normal glucose tolerance to prediabetes.
|
22163043 |
2011 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PNPLA3 I148M is associated with increased risk of prediabetes, metabolic syndrome and insulin resistance in obese patients with NAFLD.
|
31826069 |
2019 |
|
rs1501299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, in multivariate analysis, the GT genotype of rs1501299</span> increased the risk of prediabetes (<i>p</i> = 0.010; OR, 2.350; 95% CI, 1.231⁻4.486) as well as the TT genotype (<i>p</i> = 0.006; OR, 4.774; 95% CI, 1.551⁻14.693).
|
30360393 |
2018 |
|
rs1800849
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After the adjustment for possible covariates, the A allele of rs1800849 in UCP3 was significantly associated with prediabetes (aOR<sub>AA vs GG</sub> = 1.68, 95% CI: 1.02-2.78), and the association was also significant under the recessive model (aOR <sub>AA vs GA + GG</sub> = 1.64, 95% CI: 1.02-2.66).
|
29529994 |
2018 |
|
rs9356744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>CDKAL1</i> rs9356744 T allele associated with a predisposition to obesity showed a protective effect on HbA1c, 2hPG, and prediabetes.
|
29933462 |
2018 |
|
rs4607517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genetic variant near the glucokinase gene (rs4607517) was significantly associated with progression to prediabetes or diabetes (hazard ratio 1·27, 1·16-1·38; p=1·70 × 10(-7)).
|
26577716 |
2016 |
|
rs10811661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study suggested that the CDKN2A-rs10811661 polymorphism, waist-hip ratio, systolic blood pressure, and dyslipidemia were significantly associated with the increased risk of prediabetes in a Vietnamese population.
|
26334876 |
2015 |
|
rs4402960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians.
|
25755232 |
2015 |
|
rs5215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and prediabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11.
|
25755232 |
2015 |
|
rs7754840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and prediabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11.
|
25755232 |
2015 |
|
rs10986663
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele G of SNP rs10986663 in BIP gene was associated with a decreased risk of prediabetes (OR = 0.699, 95% CI: 0.539-0.907, P = 0.007).
|
24985580 |
2014 |
|
rs1408888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele of rs1408888 of DACH1 was associated with YOD, prediabetes and CVD in Chinese.
|
24465431 |
2014 |
|
rs1884613
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.
|
25400315 |
2014 |
|
rs2293855
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes.
|
24937802 |
2014 |
|
rs867529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele C of SNP rs867529 at PERK locus was a risk factor for prediabetes, with the carriers of C allele genotype at a higher risk of prediabetes compared to non-carriers (OR = 1.279, 95% CI: 1.013-1.614, P = 0.039, after adjustment for age, sex and body mass index (BMI).
|
24985580 |
2014 |