|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system.
|
30530920 |
2018 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In summary, the apoptotic regulator p73 also coordinates with Δ133p53 to promote DNA DSB repair, and the loss of function of p73 in DNA DSB repair may underlie spontaneous and carcinogen-induced tumorigenesis in p73 knockout mice.
|
29511339 |
2018 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
However, its N-terminal truncated isoforms have been associated with oncogenesis due to their capacity to act as dominant negatives of p53 and the transactivation (TA) isoforms of p73.
|
26182360 |
2015 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
p53 family proteins and VEGF play a pivotal role in colorectal carcinogenesis. p53 prognostic potential is augmented by p73 and p63 aberrations indicating a synergistic effect between the three family members.
|
23996743 |
2014 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The transcription factor p73 belongs to the p53-family and regulates tumorigenesis via its two N-terminal isoforms, with (TAp73) or without (ΔNp73) a transactivation domain.
|
25514460 |
2014 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, the impact of p73 on tumorigenesis depends on a subtle balance between tumor-promoting and -suppressing isoforms.
|
24742294 |
2014 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This is in agreement with the possible role of p73 in cervical carcinogenesis, namely, in human papillomavirus-infected transition zone subjected to the action of estrogens and in conjunction with disruption of differentiation program of this squamous epithelium that occurs in HSIL phase before the next step to invasiveness and squamous cervical cancer.
|
21711160 |
2012 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our recent study revealed miR-1246 as a novel target of p53 and its analogs p63 and p73 to suppress the expression of DYRK1A and consequently activate NFAT, both of which are associated with Down syndrome and possibly with tumorigenesis.
|
22751441 |
2012 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that p73 may serve as a tumor suppressor gene and its expression plays a role in tumorigenesis in Japanese patients with breast cancer.
|
21933556 |
2011 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We generated an mTOR-p73 signature that is enriched for p73 target genes and miRNAs that are involved in mesenchymal differentiation and tumorigenesis, can classify rhabdomyosarcomas by clinical subtype, and can predict patient outcome.
|
21245298 |
2011 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The ultimate effect of p73 in oncogenesis is thought to depend on the apoptotic TA to antiapoptotic DeltaN isoforms' ratio.
|
20528922 |
2010 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the tumor suppressor function of p53 is clearly defined, the role of p73 in tumorigenesis is still a matter of debate.
|
20676143 |
2010 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Based on the functional interaction between p53 and p73 in carcinogenesis, we investigated the combined effect of p73 G4C14-to-A4T14 and p53 gene polymorphisms and their interaction with selected environmental factors, on the risk for gastric cancer in a hospital-based case-control study conducted in Italy.
|
19386249 |
2009 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Variation in p73 may alter the interaction between the E6 protein and p73 and, thus, alter the risk for HPV-associated carcinogenesis.
|
18988287 |
2008 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this minireview, we describe the contribution of the p53, p63, and p73 to human pathology with emphasis on their different roles in development and tumorigenesis.
|
18348649 |
2008 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Although tumors show changes in the expression level of p73 and differences in the expression pattern of p73 isoforms, mutations are not commonly observed making it difficult to infer p73's role in tumorigenesis.
|
18583938 |
2008 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This review is focused on recent findings leaving no doubt that N-terminally truncated p73 proteins are operative during oncogenesis, thus underscoring its significance as a marker for disease severity in patients and as target for cancer therapy.
|
18302944 |
2008 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our data also indicate that interactions between p63 and p73 play an important role in tumorigenesis of EBD carcinoma.
|
17385050 |
2007 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Our results indicate the involvement of p73 protein in MB tumorigenesis and define TP73 as a potential prognostic and therapeutic target for medulloblastoma.
|
17912537 |
2007 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Both p63 and p73 exhibit tissue-specific roles in normal development and a complex contribution to tumorigenesis that is due to their expression as multiple protein isoforms.
|
17334395 |
2007 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, it plays a role in carcinogenesis and controls tumor sensitivity to treatment. p73 is commonly expressed in tumor cells in hematological malignancies.
|
16541141 |
2006 |
|
ARHGAP24
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data provide evidence that the p73 gene functions as an important regulator of telomerase activity with implications for embryonic development, cellular differentiation and tumorigenesis.
|
16205639 |
2006 |
|
ARHGAP24
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Mutations in p73 are rare in cancer.Emerging evidence suggests that the relative expression of various p73 isoforms may contribute to tumorigenesis.
|
16980297 |
2006 |
|
ARHGAP24
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To determine how p63 and p73 are involved in tumorigenesis and normal development, we used cDNA microarray to examine 9216 genes in human colorectal cancer cells.
|
15856012 |
2005 |