Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 Biomarker disease CTD_human Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects. 20054000 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 AlteredExpression disease BEFREE Given that etanercept can be used to successfully treat SJS/TEN and TNF-alpha levels are elevated in TSS, if a dermatologist chooses to treat TEN with etanercept, consideration of TSS on the differential should not necessarily exclude etanercept as a reasonable treatment option. 30175438 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 AlteredExpression disease BEFREE Although intact TSST1 causes lethal shock in vivo, the individual domains of this molecule may have therapeutic potential: the N-terminal domain to antagonize lymphocyte activation and TNF release during acute TSST1-precipitated toxic shock syndrome, and the C-terminal domain to stimulate antitumor responses without MHC II binding. 9551921 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 AlteredExpression disease BEFREE Major histocompatibility complex (MHC) class II engagement by toxic shock syndrome toxin 1 (TSST-1) transduces signals leading to proinflammatory cytokine gene expression (tumor necrosis factor alpha [TNF-alpha]) in human monocytes. 10603377 2000
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 Therapeutic disease RGD Platelet activating factor (PAF) and tumor necrosis factor-alpha (TNF alpha) interactions in endotoxemic shock: studies with BN 50739, a novel PAF antagonist. 2213560 1990
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 Biomarker disease RGD [The effect of transmembrane- and secreted-tumor necrosis factor-alpha on shock liver]. 12622907 2002
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.540 Biomarker disease BEFREE Using a matrigel invasion assay, we showed that TSS significantly attenuated invasive rates in TNF-α-stimulated LNCaP prostate carcinoma cells. 25168152 2014
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.500 Biomarker disease RGD Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock. 16601845 2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.500 Biomarker disease CTD_human Expression of inducible nitric oxide synthase in failing and non-failing human heart. 8745224 1996
Entrez Id: 358
Gene Symbol: AQP1
AQP1 		0.300 Biomarker disease CTD_human Induced expression and functional effects of aquaporin-1 in human leukocytes in sepsis. 24028651 2013
Entrez Id: 728
Gene Symbol: C5AR1
C5AR1 		0.300 Biomarker disease CTD_human Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. 18063050 2008
Entrez Id: 2638
Gene Symbol: GC
GC 		0.300 Biomarker disease CTD_human Comparison of rocket and crossed immuno-electrophoresis assays for determination of the level of actin complexing of Gc globulin. 17852808 2007
Entrez Id: 3122
Gene Symbol: HLA-DRA
HLA-DRA 		0.300 Biomarker disease CTD_human Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression? 28771573 2017
Entrez Id: 2
Gene Symbol: A2M
A2M 		0.200 Therapeutic disease RGD Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock. 2424486 1986
Entrez Id: 4158
Gene Symbol: MC2R
MC2R 		0.200 Biomarker disease RGD Metallothionein and zinc metabolism in endotoxin shock rats. 2822467 1987
Entrez Id: 6402
Gene Symbol: SELL
SELL 		0.200 Biomarker disease RGD GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. 19375498 2009
Entrez Id: 4282
Gene Symbol: MIF
MIF 		0.200 Biomarker disease RGD [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats]. 17565848 2007
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.200 Biomarker disease RGD Protective effects of hemin pretreatment combined with ulinastatin on septic shock in rats. 18208666 2008
Entrez Id: 4282
Gene Symbol: MIF
MIF 		0.200 Biomarker disease RGD Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. 17381395 2007
Entrez Id: 887
Gene Symbol: CCKBR
CCKBR 		0.200 Biomarker disease RGD Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats. 15948246 2005
Entrez Id: 2026
Gene Symbol: ENO2
ENO2 		0.200 Biomarker disease RGD [Changes of serum neuron specific enolase in rats with septic shock]. 17083782 2006
Entrez Id: 6915
Gene Symbol: TBXA2R
TBXA2R 		0.200 Therapeutic disease RGD Protective effects of BAY U 3405, a thromboxane A2 receptor antagonist, in endotoxin shock. 7816742 1995
Entrez Id: 133
Gene Symbol: ADM
ADM 		0.200 Biomarker disease RGD The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway. 17766482 2007
Entrez Id: 1991
Gene Symbol: ELANE
ELANE 		0.200 Therapeutic disease RGD Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats. 18323746 2008
Entrez Id: 133
Gene Symbol: ADM
ADM 		0.200 Biomarker disease RGD Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. 17318497 2007