×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
SusceptibilityMutation
disease
ORPHANET
Mutations in SUFU predispose to medulloblastoma.
12068298
2002
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
CausalMutation
disease
CLINVAR
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
GeneticVariation
disease
BEFREE
The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation.
12150819
2002
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
SusceptibilityMutation
disease
ORPHANET
The SUFU mutations were identified in two of the 16 individuals with desmoplastic medulloblastomas .
21188540
2011
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
Biomarker
disease
BEFREE
Previous studies revealed mutations in genes encoding members of the sonic hedgehog pathway, including PTCH, SMOH and SUFUH in DMB s.
16400626
2006
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
SusceptibilityMutation
disease
ORPHANET
Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations.
19833601
2010
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
SusceptibilityMutation
disease
ORPHANET
These data indicate that germline SUFU mutations were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3 years of age.
22508808
2012
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
Biomarker
disease
GENOMICS_ENGLAND
Germline mutations in SUFU cause Gorlin syndrome-associated childhood medulloblastoma and redefine the risk associated with PTCH1 mutations.
25403219
2014
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
Biomarker
disease
CTD_human
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
GeneticVariation
disease
BEFREE
The SUFU mutations were identified in two of the 16 individuals with desmoplastic medulloblastomas .
21188540
2011
×
Entrez Id:
51684
Gene Symbol:
SUFU
SUFU
0.740
GeneticVariation
disease
BEFREE
These data indicate that germline SUFU mutations were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3 years of age.
22508808
2012
×
Entrez Id:
5727
Gene Symbol:
PTCH1
PTCH1
0.320
Biomarker
disease
CTD_human
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.
18347096
2008
×
Entrez Id:
5727
Gene Symbol:
PTCH1
PTCH1
0.320
Biomarker
disease
CTD_human
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
19155313
2009
×
Entrez Id:
5727
Gene Symbol:
PTCH1
PTCH1
0.320
Biomarker
disease
CTD_human
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.
19213072
2009
×
Entrez Id:
5727
Gene Symbol:
PTCH1
PTCH1
0.320
Biomarker
disease
BEFREE
Previous studies revealed mutations in genes encoding members of the sonic hedgehog pathway, including PTCH , SMOH and SUFUH in DMB s.
16400626
2006
×
Entrez Id:
5727
Gene Symbol:
PTCH1
PTCH1
0.320
GeneticVariation
disease
BEFREE
The authors present the case of a 2.5-year-old African-American boy with desmoplastic medulloblastoma (MB) and nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, an autosomal dominant disorder resulting from mutations in the patched (PTCH ) gene that predisposes to neoplasias (including basal cell carcinomas [BCCs] and MB ) and to widespread congenital malformations.
17328283
2006
×
Entrez Id:
23081
Gene Symbol:
KDM4C
KDM4C
0.310
Biomarker
disease
CTD_human
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
19270706
2009
×
Entrez Id:
23081
Gene Symbol:
KDM4C
KDM4C
0.310
GeneticVariation
disease
BEFREE
Further analysis of the 9p and 17q22-q24 amplicons by array-based CGH (matrix-CGH) and candidate gene analyses revealed amplification of JMJD2C at 9p24 in one DMB and amplification of RPS6KB1, APPBP2, PPM1D and BCAS3 from 17q23 in three DMBs.
16400626
2006
×
Entrez Id:
6447
Gene Symbol:
SCG5
SCG5
0.300
Biomarker
disease
CTD_human
SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas.
17334394
2007
×
Entrez Id:
898
Gene Symbol:
CCNE1
CCNE1
0.300
Biomarker
disease
CTD_human
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
19270706
2009
×
Entrez Id:
1021
Gene Symbol:
CDK6
CDK6
0.300
Biomarker
disease
CTD_human
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
19270706
2009
×
Entrez Id:
10389
Gene Symbol:
SCML2
SCML2
0.300
Biomarker
disease
CTD_human
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
19270706
2009
×
Entrez Id:
92335
Gene Symbol:
STRADA
STRADA
0.300
Biomarker
disease
CTD_human
A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.
21652733
2011
×
Entrez Id:
7409
Gene Symbol:
VAV1
VAV1
0.300
Biomarker
disease
CTD_human
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
19270706
2009
×
Entrez Id:
5156
Gene Symbol:
PDGFRA
PDGFRA
0.300
Biomarker
disease
CTD_human
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
19270706
2009