Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4436
Gene Symbol: MSH2
MSH2 		0.010 GeneticVariation disease BEFREE Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6. 29302048 2018
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.010 GeneticVariation disease BEFREE Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6. 29302048 2018
Entrez Id: 10278
Gene Symbol: EFS
EFS 		0.010 Biomarker disease BEFREE Postoperative primary CHT was found significantly to influence the survival of classic medulloblastoma (CMB) (OS p<0.001, EFS p<0.001), SHH subgroup (OS p = 0.020, EFS p = 0.049) and WNT subgroup (OS p = 0.003, EFS p = 0.016) but not in desmoplastic/nodular medulloblastoma (DMB) (OS p = 0.361, EFS p = 0.834) and Non-SHH/WNT subgroup (OS p = 0.127, EFS p = 0.055). 24932704 2014
Entrez Id: 6469
Gene Symbol: SHH
SHH 		0.010 Biomarker disease BEFREE Our study showed postoperative primary CHT significantly influence the survival of CMB, SHH subgroup and WNT subgroup but not in DMB and Non-SHH/WNT subgroup of MB. 24932704 2014
Entrez Id: 2735
Gene Symbol: GLI1
GLI1 		0.010 Biomarker disease BEFREE Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes. 18924150 2009
Entrez Id: 6198
Gene Symbol: RPS6KB1
RPS6KB1 		0.010 AlteredExpression disease BEFREE Among the 17q23 genes, RPS6KB1 showed markedly elevated transcript levels as compared to normal cerebellum in five of six DMBs and four of five classic medulloblastomas investigated. 16400626 2006
Entrez Id: 54828
Gene Symbol: BCAS3
BCAS3 		0.010 Biomarker disease BEFREE Further analysis of the 9p and 17q22-q24 amplicons by array-based CGH (matrix-CGH) and candidate gene analyses revealed amplification of JMJD2C at 9p24 in one DMB and amplification of RPS6KB1, APPBP2, PPM1D and BCAS3 from 17q23 in three DMBs. 16400626 2006
Entrez Id: 6608
Gene Symbol: SMO
SMO 		0.010 Biomarker disease BEFREE Previous studies revealed mutations in genes encoding members of the sonic hedgehog pathway, including PTCH, SMOH and SUFUH in DMBs. 16400626 2006
Entrez Id: 6664
Gene Symbol: SOX11
SOX11 		0.010 AlteredExpression disease BEFREE Sox4 and Sox11 were strongly expressed in most classical medulloblastomas but only weakly in desmoplastic medulloblastomas. 12125983 2002
Entrez Id: 6659
Gene Symbol: SOX4
SOX4 		0.010 AlteredExpression disease BEFREE Sox4 and Sox11 were strongly expressed in most classical medulloblastomas but only weakly in desmoplastic medulloblastomas. 12125983 2002
Entrez Id: 5079
Gene Symbol: PAX5
PAX5 		0.010 AlteredExpression disease BEFREE These data suggest that deregulated expression of PAX5 correlates positively with cell proliferation and inversely with neuronal differentiation in desmoplastic medulloblastoma. 7777574 1995
Entrez Id: 6046
Gene Symbol: BRD2
BRD2 		0.300 Biomarker disease CTD_human BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. 24231268 2013
Entrez Id: 1021
Gene Symbol: CDK6
CDK6 		0.300 Biomarker disease CTD_human Inhibition of cyclin-dependent kinase 6 suppresses cell proliferation and enhances radiation sensitivity in medulloblastoma cells. 23138228 2013
Entrez Id: 8019
Gene Symbol: BRD3
BRD3 		0.300 Biomarker disease CTD_human BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. 24231268 2013
Entrez Id: 23476
Gene Symbol: BRD4
BRD4 		0.300 Biomarker disease CTD_human BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. 24231268 2013
Entrez Id: 92335
Gene Symbol: STRADA
STRADA 		0.300 Biomarker disease CTD_human A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. 21652733 2011
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1 		0.300 Biomarker disease CTD_human RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines. 21880625 2011
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG 		0.300 Biomarker disease CTD_human A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. 21652733 2011
Entrez Id: 2100
Gene Symbol: ESR2
ESR2 		0.300 Therapeutic disease CTD_human Protective role of 17 β-estradiol on medulloblastoma development in Patched 1 heterozygous mice. 21351254 2010
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		0.300 Biomarker disease CTD_human Double high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for primary disseminated medulloblastoma: a report of 3 cases. 20168248 2010
Entrez Id: 898
Gene Symbol: CCNE1
CCNE1 		0.300 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009
Entrez Id: 1021
Gene Symbol: CDK6
CDK6 		0.300 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009
Entrez Id: 10389
Gene Symbol: SCML2
SCML2 		0.300 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009
Entrez Id: 7409
Gene Symbol: VAV1
VAV1 		0.300 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009
Entrez Id: 5156
Gene Symbol: PDGFRA
PDGFRA 		0.300 Biomarker disease CTD_human Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. 19270706 2009