Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7498
Gene Symbol: XDH
XDH 		0.200 Biomarker disease RGD Lack of conversion of xanthine dehydrogenase to xanthine oxidase during warm renal ischemia. 2253787 1990
Entrez Id: 7429
Gene Symbol: VIL1
VIL1 		0.010 Biomarker disease BEFREE Plasmatic Villin 1 Is a Novel In Vivo Marker of Proximal Tubular Cell Injury During Renal Ischemia-Reperfusion. 28704336 2017
Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1 		0.010 Biomarker disease BEFREE Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg body weight). 20877722 2010
Entrez Id: 7402
Gene Symbol: UTRN
UTRN 		0.020 Biomarker disease BEFREE Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway. 29704468 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN 		0.020 AlteredExpression disease BEFREE We recently found dysregulation of mitochondrial dynamics caused by increased Drp1 expression and cellular apoptosis of the heart in an experimental AKI animal model of renal ischemia-reperfusion. 27349577 2016
Entrez Id: 7295
Gene Symbol: TXN
TXN 		0.010 Biomarker disease BEFREE The present findings suggest that TRX is retained in mTAL and secreted from proximal tubuli into urine during renal ischemia/reperfusion. 12969145 2003
Entrez Id: 7442
Gene Symbol: TRPV1
TRPV1 		0.010 PosttranslationalModification disease BEFREE TRPV1 protects renal ischemia-reperfusion injury in diet-induced obese mice by enhancing CGRP release and increasing renal blood flow. 30834186 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.010 Biomarker disease BEFREE Time-dependent p53 inhibition determines senescence attenuation and long-term outcome after renal ischemia-reperfusion. 30785352 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 Biomarker disease BEFREE <i>In vivo</i> studies using <i>Ripk3</i>- or <i>Mlkl</i>-deficient mice validated kidney ischemia reperfusion injury and high-dose tumor necrosis factor (TNF) availability, as druggable targets in necroptotic-mediated pathologies. 30842945 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.030 AlteredExpression disease BEFREE Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity. 29625388 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.030 Biomarker disease BEFREE However, HMGB1 blockade in a renal ischemia reperfusion model reduced pulmonary neutrophil infiltration independent from TLR4. 24646859 2014
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.030 Biomarker disease BEFREE Up-Regulation of HMGB1 Exacerbates Renal Ischemia-Reperfusion Injury by Stimulating Inflammatory and Immune Responses through the TLR4 Signaling Pathway in Mice. 28472797 2017
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.020 Biomarker disease BEFREE Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney. 28857508 2018
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.020 Biomarker disease BEFREE Our study compared and contrasted the effects of renal ischemia in wild-type mice and mice deficient in TLR2, MyD88, Trif, and MyD88xTrif. 17475853 2007
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.010 Biomarker disease BEFREE Thus, isoflurane causes TGF-β1-dependent induction of renal tubular CD73 and adenosine generation to protect against renal ischemia and reperfusion injury. 23423261 2013
Entrez Id: 7033
Gene Symbol: TFF3
TFF3 		0.010 Biomarker disease BEFREE WPB exocytosis contributed to IRI-associated mobilization of endothelial progenitor cells and hematopoietic stem cells, and ITF 1697 blunted their mobilization. 22160777 2012
Entrez Id: 6772
Gene Symbol: STAT1
STAT1 		0.010 Biomarker disease BEFREE In vivo, STAT1<sup>-/-</sup> mice displayed less acute tubular necrosis and decreased macrophage infiltration 24 h after renal ischemia. 30403164 2019
Entrez Id: 6609
Gene Symbol: SMPD1
SMPD1 		0.010 Biomarker disease BEFREE Juxtanuclear accumulation of ATG9A and defective autophagy are also evident in tissues of smpd1-deficient mice with a subsequent inability to cope with kidney ischemia-reperfusion stress. 27070082 2016
Entrez Id: 6524
Gene Symbol: SLC5A2
SLC5A2 		0.010 Biomarker disease BEFREE Sodium glucose cotransporter 2 inhibition and renal ischemia: implications for future clinical trials. 30143067 2018
Entrez Id: 51310
Gene Symbol: SLC22A17
SLC22A17 		0.010 AlteredExpression disease BEFREE Renal protein expression of 24p3R, which is expressed at renal distal tubules and uptake NGAL, decreased in rats with renal ischaemia for 45 min. 31211866 2019
Entrez Id: 51548
Gene Symbol: SIRT6
SIRT6 		0.010 AlteredExpression disease BEFREE Sirt6 is markedly upregulated during fibrogenesis following obstructed nephropathy and kidney ischemia-reperfusion injury. 31787254 2020
Entrez Id: 23410
Gene Symbol: SIRT3
SIRT3 		0.010 Biomarker disease BEFREE Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation. 30442253 2018
Entrez Id: 22933
Gene Symbol: SIRT2
SIRT2 		0.010 Biomarker disease BEFREE The administration of SIRT2 inhibitor AGK2 prior to renal ischemia decreased significantly the number of apoptotic renal tubular cells and alleviated ultrastructure injury. 28078537 2017
Entrez Id: 140885
Gene Symbol: SIRPA
SIRPA 		0.010 Biomarker disease BEFREE Mice lacking SIRP-α cytoplasmic signaling (SIRP-α<sup>mut</sup>) and wild-type (WT) littermate controls underwent renal ischemia and reperfusion. 31370677 2019
Entrez Id: 6402
Gene Symbol: SELL
SELL 		0.010 Biomarker disease BEFREE Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion. 17525255 2007