Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 317
Gene Symbol: APAF1
APAF1 		0.200 Therapeutic disease RGD Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. 25330150 2014
Entrez Id: 7498
Gene Symbol: XDH
XDH 		0.200 Biomarker disease RGD Lack of conversion of xanthine dehydrogenase to xanthine oxidase during warm renal ischemia. 2253787 1990
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.050 Biomarker disease BEFREE A novel role of HIF-1α/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion in mice. 29633855 2019
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.050 Biomarker disease BEFREE Ferulic Acid Protected from Kidney Ischemia Reperfusion Injury in Mice: Possible Mechanism Through Increasing Adenosine Generation via HIF-1α. 30143933 2018
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.050 Biomarker disease BEFREE Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1α. 27127787 2016
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.050 Biomarker disease BEFREE Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival. 22432008 2012
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A 		0.050 Biomarker disease BEFREE In a model of renal ischemia-reperfusion injury, xenon provided morphologic and functional renoprotection; hydrodynamic injection of HIF-1alpha small interfering RNA demonstrated that this protection is HIF-1alpha dependent. 19144758 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.030 AlteredExpression disease BEFREE Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity. 29625388 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.030 Biomarker disease BEFREE Up-Regulation of HMGB1 Exacerbates Renal Ischemia-Reperfusion Injury by Stimulating Inflammatory and Immune Responses through the TLR4 Signaling Pathway in Mice. 28472797 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.030 Biomarker disease BEFREE However, HMGB1 blockade in a renal ischemia reperfusion model reduced pulmonary neutrophil infiltration independent from TLR4. 24646859 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.020 Biomarker disease BEFREE AR/miR-21 axis could be a potential therapeutic target for the kidney ischemia injury. 31632533 2019
Entrez Id: 2056
Gene Symbol: EPO
EPO 		0.020 Biomarker disease BEFREE We postulate that chronic intermittent hypotension and renal ischemia may lead to erythropoietin secretion, and this cascade could represent a newly recognized cause of secondary erythrocytosis. 31266452 2019
Entrez Id: 2056
Gene Symbol: EPO
EPO 		0.020 Biomarker disease BEFREE Rats were randomly assigned to four experimental groups following median laparotomy and right nephrectomy: Sham (n = 6); 30-min left renal ischemia (RI) only (n = 20); RI + rIC (n = 20) (four 5-min cycles of limb ischemia interspersed with 5-min limb reperfusion during RI); and RI + erythropoietin pretreatment (EPO) (n = 20). 29846359 2019
Entrez Id: 3934
Gene Symbol: LCN2
LCN2 		0.020 Biomarker disease BEFREE Renal protein expression of 24p3R, which is expressed at renal distal tubules and uptake NGAL, decreased in rats with renal ischaemia for 45 min. 31211866 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.020 Biomarker disease BEFREE Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney. 28857508 2018
Entrez Id: 8562
Gene Symbol: DENR
DENR 		0.020 Biomarker disease BEFREE Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway. 29704468 2018
Entrez Id: 7402
Gene Symbol: UTRN
UTRN 		0.020 Biomarker disease BEFREE Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway. 29704468 2018
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.020 Biomarker disease BEFREE Upregulation of heme oxygenase 1 (HO-1) attenuates kidney damage, oxidative stress and inflammatory reaction during renal ischemia/ reperfusion injury. 29593125 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33 		0.020 Biomarker disease BEFREE We examined the role of the nuclear alarmin IL-33 in tissue injury and innate immune response triggered by experimental kidney ischemia-reperfusion. 29436517 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33 		0.020 Biomarker disease BEFREE Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury. 29295873 2018
Entrez Id: 23604
Gene Symbol: DAPK2
DAPK2 		0.020 Biomarker disease BEFREE Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway. 29704468 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.020 AlteredExpression disease BEFREE Accumulating evidence suggests that miR-21 overexpression protects against kidney ischemia injury. 30013485 2018
Entrez Id: 10059
Gene Symbol: DNM1L
DNM1L 		0.020 Biomarker disease BEFREE Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway. 29704468 2018
Entrez Id: 1400
Gene Symbol: CRMP1
CRMP1 		0.020 Biomarker disease BEFREE Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway. 29704468 2018
Entrez Id: 23569
Gene Symbol: PADI4
PADI4 		0.020 Biomarker disease BEFREE Notably, transfer of neutrophils from wild-type, but not from PAD4-deficient mice, was sufficient to restore renal neutrophil extracellular trap formation and impair kidney function following renal ischemia/reperfusion. 29061334 2018