Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.240 Biomarker disease BEFREE PAI-1 is an essential repressor of cardiac fibrosis in mammals. 28588076 2017
Entrez Id: 4306
Gene Symbol: NR3C2
NR3C2 		0.030 Biomarker disease BEFREE Mineralocorticoid Receptor Signaling as a Therapeutic Target for Renal and Cardiac Fibrosis. 28611666 2017
Entrez Id: 1906
Gene Symbol: EDN1
EDN1 		0.230 Biomarker disease BEFREE Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac fibrosis. 28713274 2017
Entrez Id: 406953
Gene Symbol: MIR18A
MIR18A 		0.010 Biomarker disease BEFREE MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway. 28733035 2017
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3 		0.100 Biomarker disease BEFREE Galectin-3 has been proposed as a novel biomarker of heart failure and cardiac fibrosis, and may also be associated with fibrosis of other organs such as the kidney. 28865675 2018
Entrez Id: 64127
Gene Symbol: NOD2
NOD2 		0.010 Biomarker disease BEFREE NOD2 knockdown<sup>(-/-</sup><sup>)</sup> mice were rescued from the detrimental CVB3-mediated effects as shown by a reduced cardiac inflammation (less cardiac infiltrates and suppression of proinflammatory cytokines), cardiac fibrosis, apoptosis, lower CAR (Coxsackievirus and adenovirus receptor) expression and CVB3 copy number, and an improved left ventricular function in NOD2<sup>-/-</sup> CVB3 mice compared with wild-type CVB3 mice. 28912259 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.070 Biomarker disease BEFREE microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. 28944900 2017
Entrez Id: 4969
Gene Symbol: OGN
OGN 		0.010 Biomarker disease BEFREE Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation. 28958774 2018
Entrez Id: 4017
Gene Symbol: LOXL2
LOXL2 		0.010 Biomarker disease BEFREE Lysyl oxidase-like 2 (LOXL2) is known to play an important role in many fibrotic conditions, including cardiac fibrosis. 29089463 2017
Entrez Id: 3290
Gene Symbol: HSD11B1
HSD11B1 		0.020 Biomarker disease BEFREE 11β-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity. 29221204 2017
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 Biomarker disease BEFREE Angiotensin II (Ang II) plays an important role on the pathogenesis of cardiac fibrosis. 29322373 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.020 Biomarker disease BEFREE IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis. 29360942 2018
Entrez Id: 960
Gene Symbol: CD44
CD44 		0.010 Biomarker disease BEFREE CD44 Deficiency in Mice Protects the Heart Against Angiotensin Ii-Induced Cardiac Fibrosis. 29470359 2019
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3 		0.100 Biomarker disease BEFREE Galectin-3 (Gal-3) is increased in heart failure (HF) and promotes cardiac fibrosis and inflammation. 29674526 2018
Entrez Id: 100302263
Gene Symbol: MIR1908
MIR1908 		0.010 Biomarker disease BEFREE MiR-1908 improves cardiac fibrosis after myocardial infarction by targeting TGF-β1. 29687863 2018
Entrez Id: 6275
Gene Symbol: S100A4
S100A4 		0.010 Biomarker disease BEFREE S100A4 may be a therapeutic target of cardiac fibrosis. 29758552 2018
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A 		0.020 Biomarker disease BEFREE DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis. 29786779 2018
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.020 Biomarker disease BEFREE Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation. 29800064 2018
Entrez Id: 407029
Gene Symbol: MIR30A
MIR30A 		0.010 Biomarker disease BEFREE miR-30a attenuates cardiac fibrosis in rats with myocardial infarction by inhibiting CTGF. 29849775 2018
Entrez Id: 6609
Gene Symbol: SMPD1
SMPD1 		0.010 Biomarker disease BEFREE Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin. 29906461 2018
Entrez Id: 142
Gene Symbol: PARP1
PARP1 		0.020 Biomarker disease BEFREE PARP-1 inhibition attenuates cardiac fibrosis induced by myocardial infarction through regulating autophagy. 30041821 2018
Entrez Id: 6869
Gene Symbol: TACR1
TACR1 		0.020 Biomarker disease BEFREE NK-1R blockade partially mitigated cardiac fibrosis while completely preventing cardiomyocyte apoptosis. 30205930 2019
Entrez Id: 407021
Gene Symbol: MIR29A
MIR29A 		0.030 Biomarker disease BEFREE microRNA-29a inhibits cardiac fibrosis in Sprague-Dawley rats by downregulating the expression of DNMT3A. 30297596 2018
Entrez Id: 367
Gene Symbol: AR
AR 		0.010 Biomarker disease BEFREE Androgen receptor regulates cardiac fibrosis in mice with experimental autoimmune myocarditis by increasing microRNA-125b expression. 30340830 2018
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.100 Biomarker disease BEFREE Angiotensin II (Ang II), an effective component of renin-angiotensin system, plays a pivotal role in cardiac fibrosis, which may further contribute to heart failure. 30369577 2018