Gene: CHEK2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency). 15472904 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women. 18706089 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations. 18930998 2009
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Pathology of breast cancer in women with constitutional CHEK2 mutations. 15803365 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large. 16914568 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population. 18484200 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group CLINVAR Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts. 17721994 2007
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. 11967536 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations. 18058223 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant. 15466005 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Absence of CHEK2 1100delC mutation in familial breast cancer cases from a South American population. 17876702 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls. 18172190 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer. 18085035 2007
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer. 17705858 2007
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining. 12094328 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk. 16671833 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE We found an even stronger significant association between the CHEK2 I157T C variant and increased risk of lobular type breast tumors (OR = 4.17, 95% CI = 2.89-6.03, P < 0.0001). 22799331 2012
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. 15649950 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts. 17721994 2007
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining. 12094328 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study. 18381420 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group CLINVAR CHEK2 contribution to hereditary breast cancer in non-BRCA families. 22114986 2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation. 18175216 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study. 18253122 2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE Such factors may not be needed for breast tumors with a defect in a non-essential gene such as CHEK2. 26553136 2015