Gene: CHEK2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. 11967536 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group LHGDN CHEKs and balances: accounting for breast cancer. 11984555 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining. 12094328 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining. 12094328 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group BEFREE We conclude that somatic CHK2 mutations are rare in breast cancer, but our results suggest a tumor suppressor function for CHK2 in a small proportion of breast tumors. 12052256 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group CTD_human Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. 11967536 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group CTD_human The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. 12690581 2003
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 AlteredExpression group BEFREE We studied CHEK2 protein expression in 111, and loss of heterozygosity at CHEK2 in 88 breast tumors from these patients. 14678969 2003
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant. 15466005 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group LHGDN CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies. 15122511 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 CausalMutation group CLINVAR Nonsense-mediated mRNA decay: terminating erroneous gene expression. 15145354 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group CTD_human CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies. 15122511 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. 14701743 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Limited relevance of the CHEK2 gene in hereditary breast cancer. 15095295 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency). 15472904 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Pathology of breast cancer in women with constitutional CHEK2 mutations. 15803365 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. 15649950 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic. 15803363 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. 15700044 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency). 15472904 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation. 16337852 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 CausalMutation group CLINVAR Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. 15649950 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large. 16914568 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 CausalMutation group CLINVAR Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. 16551709 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk. 16671833 2006