Gene: CHEK2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. 11967536 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group CTD_human Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. 11967536 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group LHGDN CHEKs and balances: accounting for breast cancer. 11984555 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group BEFREE We conclude that somatic CHK2 mutations are rare in breast cancer, but our results suggest a tumor suppressor function for CHK2 in a small proportion of breast tumors. 12052256 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining. 12094328 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining. 12094328 2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group CTD_human The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. 12690581 2003
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 AlteredExpression group BEFREE We studied CHEK2 protein expression in 111, and loss of heterozygosity at CHEK2 in 88 breast tumors from these patients. 14678969 2003
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. 14701743 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Limited relevance of the CHEK2 gene in hereditary breast cancer. 15095295 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group LHGDN CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies. 15122511 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group CTD_human CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies. 15122511 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 CausalMutation group CLINVAR Nonsense-mediated mRNA decay: terminating erroneous gene expression. 15145354 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant. 15466005 2004
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group BEFREE We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency). 15472904 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency). 15472904 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. 15649950 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 CausalMutation group CLINVAR Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. 15649950 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. 15700044 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic. 15803363 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Pathology of breast cancer in women with constitutional CHEK2 mutations. 15803365 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 GeneticVariation group LHGDN Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation. 16337852 2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 AlteredExpression group LHGDN Expression of checkpoint kinase 2 in breast carcinomas: correlation with key regulators of tumor cell proliferation, angiogenesis, and survival. 16437383 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 Biomarker group LHGDN The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry. 16492927 2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2 		0.500 CausalMutation group CLINVAR Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. 16551709 2006