Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
F2RL1 P55085 F2R like trypsin receptor 1 G-protein coupled receptor 1.5E-04 0.480 0.769
MC1R Q01726 melanocortin 1 receptor G-protein coupled receptor 8.1E-11 0.524 0.808
OPRM1 P35372 opioid receptor mu 1 G-protein coupled receptor 7.9E-11 0.457 0.808
P2RY12 Q9H244 purinergic receptor P2Y12 G-protein coupled receptor 1.7E-03 0.533 0.731
GRIN1 Q05586 glutamate ionotropic receptor NMDA type subunit 1 Ion channel 0.98 0.561 0.692
GRIN2B Q13224 glutamate ionotropic receptor NMDA type subunit 2B Ion channel 1.00 0.510 0.692
P2RX3 P56373 purinergic receptor P2X 3 Ion channel 1.0E-06 0.565 0.769
P2RX4 Q99571 purinergic receptor P2X 4 Ion channel 5.0E-12 0.547 0.808
P2RX7 Q99572 purinergic receptor P2X 7 Ion channel 3.3E-11 0.450 0.808
TRPV1 Q8NER1 transient receptor potential cation channel subfamily V member 1 Ion channel 1.0E-16 0.446 0.885
TRPA1 O75762 transient receptor potential cation channel subfamily A member 1 Ion channel 7.2E-35 0.546 0.846
ASIC3 Q9UHC3 acid sensing ion channel subunit 3 Ion channel 3.4E-07 0.663 0.538
P2RX2 Q9UBL9 purinergic receptor P2X 2 Ion channel 9.7E-13 0.585 0.769
HCN3 Q9P1Z3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 Ion channel 2.6E-05 0.792 0.308
TRPV4 Q9HBA0 transient receptor potential cation channel subfamily V member 4 Ion channel 2.2E-16 0.457 0.808
TRPM8 Q7Z2W7 transient receptor potential cation channel subfamily M member 8 Ion channel 4.6E-29 0.553 0.808
CDK5 Q00535 cyclin dependent kinase 5 Kinase 0.14 0.495 0.846
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923
MAPK3 P27361 mitogen-activated protein kinase 3 Kinase 3.7E-02 0.379 0.885
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
CALCA P01258 P06881 calcitonin related polypeptide alpha Signaling 1.6E-02 0.416 0.923
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885
PNOC Q13519 prepronociceptin Signaling 1.5E-02 0.603 0.577
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962