Disease: Hypercholesterolemia, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885
LINC01194 long intergenic non-protein coding RNA 1194 0.470 0.769
MIR505 microRNA 505 0.603 0.577
LINC01672 long intergenic non-protein coding RNA 1672 0.462 0.846
ROS1 P08922 ROS proto-oncogene 1, receptor tyrosine kinase Kinase 1.6E-72 0.439 0.885
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923
ABCG2 Q9UNQ0 ATP binding cassette subfamily G member 2 (Junior blood group) Transporter 2.1E-32 0.419 0.885
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885
HSPG2 P98160 heparan sulfate proteoglycan 2 Enzyme modulator 1.0E-19 0.438 0.885
MMP1 P03956 matrix metallopeptidase 1 Enzyme 7.7E-18 0.385 0.885
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
ANXA5 P08758 annexin A5 3.8E-15 0.458 0.769
MMP3 P08254 matrix metallopeptidase 3 Enzyme 5.7E-15 0.408 0.885
ACSS2 Q9NR19 acyl-CoA synthetase short chain family member 2 Enzyme 1.1E-13 0.506 0.808
ABCA1 O95477 ATP binding cassette subfamily A member 1 Transporter 1.5E-13 0.467 0.846
ANGPTL3 Q9Y5C1 angiopoietin like 3 Signaling 1.6E-13 0.584 0.577
OCA2 Q04671 OCA2 melanosomal transmembrane protein 2.9E-13 0.539 0.808
SCNN1A P37088 sodium channel epithelial 1 subunit alpha Ion channel 1.1E-11 0.601 0.577
SLC22A3 O75751 solute carrier family 22 member 3 Transporter 7.8E-10 0.531 0.846
GLB1 P16278 galactosidase beta 1 Enzyme 7.9E-10 0.448 0.808
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962
ADIPOQ Q15848 adiponectin, C1Q and collagen domain containing 4.6E-09 0.376 0.885
TYK2 P29597 tyrosine kinase 2 Kinase 4.5E-08 0.505 0.769
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923