rs9904341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we found that the survivin rs9904341 polymorphism was associated with an increased risk of acute pancreatitis.
|
26125713 |
2015 |
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Mutation p.N34S in SPINK1 may predispose patients to acute pancreatitis, especially in those abusing alcohol, and may promote a more severe course of the disease.
|
26100556 |
2015 |
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Six children with severe acute pancreatitis had SPINK1 N34S mutations (25%, p<0.05), and 4 were homozygous.
|
25981744 |
2015 |
rs1223231582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Six children with severe acute pancreatitis had SPINK1 N34S mutations (25%, p<0.05), and 4 were homozygous.
|
25981744 |
2015 |
rs1143634
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Multivariate regression analyses showed that subjects carrying the rs1143634 TT genotype had a significantly increased risk of acute pancreatitis, with an adjusted odds ratio (95% confidence interval) of 2.11 (1.03-4.51).
|
25730036 |
2015 |
rs5743795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, TLR6 rs5743795 GG genotype patients had a lower risk for severe AP (GG OR, 0.909; P < 0.05).
|
25423559 |
2015 |
rs5029924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither of these SNPs was associated with susceptibility to AP; however, acute pancreatitis patients who possessed the T allele of rs5029924 were more likely to experience systemic inflammatory response syndrome.
|
25050625 |
2014 |
rs4986790
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.
|
24914392 |
2014 |
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.
|
24914392 |
2014 |
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The p.N34S mutation in SPINK1 gene was found more frequently in patients with AP in the Indian population, irrespective of disease etiology and whether the disease was recurrent or not, and was associated with disease onset at an earlier age.
|
24844923 |
2014 |
rs5707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The renin rs5707 G (rather than A) allele was associated with AP (P = 0.002), infected necrosis (P = 0.025) and mortality (P = 0.046).
|
24743610 |
2015 |
rs1451659304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data from this study showed that compound heterozygote mutations of A98T and L279V inactivate lipoprotein lipase enzymatic activity and contribute to severe HTG and acute pancreatitis in two Chinese patients.
|
24646025 |
2014 |
rs145657341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data from this study showed that compound heterozygote mutations of A98T and L279V inactivate lipoprotein lipase enzymatic activity and contribute to severe HTG and acute pancreatitis in two Chinese patients.
|
24646025 |
2014 |
rs371282890
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data from this study showed that compound heterozygote mutations of A98T and L279V inactivate lipoprotein lipase enzymatic activity and contribute to severe HTG and acute pancreatitis in two Chinese patients.
|
24646025 |
2014 |
rs773891125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data from this study showed that compound heterozygote mutations of A98T and L279V inactivate lipoprotein lipase enzymatic activity and contribute to severe HTG and acute pancreatitis in two Chinese patients.
|
24646025 |
2014 |
rs1800896
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs1143634
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs4073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed evidence for significant association between IL-8 -251 T/A (rs4073) polymorphism and AP risk, suggesting that IL-8 -251 A allele was associated with an increased risk of AP (for A allele vs. T allele: OR = 1.36, 95 % CI 1.05-1.76, p = 0.02; for A/A vs. T/T: OR = 2.28, 95 % CI 1.08-4.81, p = 0.03; for A/A+T/A vs. T/T: OR = 1.40, 95 % CI 1.11-1.77, p = 0.005).
|
24072654 |
2013 |
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs1800796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
rs17107315
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Patients bearing the N34S G allele exhibited a 10-fold increased risk of developing AP compared with controls, suggesting that the SPINK1 N34S mutation represents an etiologic risk factor for AP in our Mexican pediatric patients.
|
22699143 |
2012 |
rs111033565
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The study's objective was to assess the association between the PRSS1 R122H and N29I and the SPINK1 N34S mutations and acute pancreatitis (AP) and recurrent pancreatitis in Mexican pediatric patients.
|
22699143 |
2012 |