|
rs4073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrated a suggestive result that people who carried the risk A allele of the IL-8 rs4073 polymorphism may be more sensitive to acute pancreatitis.
|
31340771 |
2019 |
|
rs12688220
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Meta-analyses of all AP patients depicted significant (p-value < 0.05) associations for rs10273639 (odds ratio (OR) 0.88, 95% confidence interval (CI) 0.81-0.97, p-value 0.01), rs7057398 (OR 1.27, 95% CI 1.07-1.5, p-value 0.005), and rs12688220 (OR 1.32, 95% CI 1.12-1.56, p-value 0.001).
|
29884332 |
2018 |
|
rs7057398
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Meta-analyses of all AP patients depicted significant (p-value < 0.05) associations for rs10273639 (odds ratio (OR) 0.88, 95% confidence interval (CI) 0.81-0.97, p-value 0.01), rs7057398 (OR 1.27, 95% CI 1.07-1.5, p-value 0.005), and rs12688220 (OR 1.32, 95% CI 1.12-1.56, p-value 0.001).
|
29884332 |
2018 |
|
rs1143634
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Multivariate regression analyses showed that subjects carrying the rs1143634 TT genotype had a significantly increased risk of acute pancreatitis, with an adjusted odds ratio (95% confidence interval) of 2.11 (1.03-4.51).
|
25730036 |
2015 |
|
rs1223231582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Six children with severe acute pancreatitis had SPINK1 N34S mutations (25%, p<0.05), and 4 were homozygous.
|
25981744 |
2015 |
|
rs1143634
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
|
rs4073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed evidence for significant association between IL-8 -251 T/A (rs4073) polymorphism and AP risk, suggesting that IL-8 -251 A allele was associated with an increased risk of AP (for A allele vs. T allele: OR = 1.36, 95 % CI 1.05-1.76, p = 0.02; for A/A vs. T/T: OR = 2.28, 95 % CI 1.08-4.81, p = 0.03; for A/A+T/A vs. T/T: OR = 1.40, 95 % CI 1.11-1.77, p = 0.005).
|
24072654 |
2013 |
|
rs1223231582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients bearing the N34S G allele exhibited a 10-fold increased risk of developing AP compared with controls, suggesting that the SPINK1 N34S mutation represents an etiologic risk factor for AP in our Mexican pediatric patients.
|
22699143 |
2012 |
|
rs61734659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs748405415
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 261 patients with AP (174 with a sentinel attack, and 87 with recurrent attacks) and healthy controls were genotyped for the p.R122H mutation in the PRSS1 gene, p.N34S and IVS3 + 2T > C variants in the SPINK1 gene, the p.G191R variant in the anionic trypsinogen gene, the p.E32del variant in the mesotrypsinogen (PRSS3) gene, and the -2518G > A variant in the monocyte chemoattractant protein-1 gene by polymerase chain reaction-restriction enzyme digestion and direct sequencing.
|
21303407 |
2011 |
|
rs61734659
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan.
|
19052022 |
2009 |
|
rs748405415
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The p.G191R variant protected against alcoholic and idiopathic chronic pancreatitis as well as alcoholic acute pancreatitis in Japan.
|
19052022 |
2009 |
|
rs777418530
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SPINK1 N34S variant is associated with acute pancreatitis.
|
18617776 |
2008 |
|
rs777418530
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPINK1 N34S mutation enhances the susceptibility of AP.
|
15782101 |
2005 |
|
rs11209026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Epistasis analysis revealed that AP susceptibility was increased by interaction between <i>IL23R</i> rs11209026 and <i>TNF</i> rs1800629 (p = 1.205 × 10<sup>-5</sup>; OR<sub>interaction</sub> = 4.031).
|
31044631 |
2019 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Epistasis analysis revealed that AP susceptibility was increased by interaction between <i>IL23R</i> rs11209026 and <i>TNF</i> rs1800629 (p = 1.205 × 10<sup>-5</sup>; OR<sub>interaction</sub> = 4.031).
|
31044631 |
2019 |
|
rs213950
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the aim of our study was to determine the functional importance of common cystic fibrosis transmembrane conductance regulator variations IVS8-poly T, R117H, and M470V for the severity of acute pancreatitis.
|
30132293 |
2019 |
|
rs78655421
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the aim of our study was to determine the functional importance of common cystic fibrosis transmembrane conductance regulator variations IVS8-poly T, R117H, and M470V for the severity of acute pancreatitis.
|
30132293 |
2019 |
|
rs4251961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL1RN -1129T>C (rs4251961) genotypes might be associated with a significant increase of AP risk in a Korean ethnic group.
|
29117667 |
2018 |
|
rs1052571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs1132312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs121912654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of GSTM1 is associated with increased susceptibility for AP, and the GSTP1 Val105Ile SNP is associated with an increased risk for AP in men.
|
27984487 |
2017 |
|
rs142907823
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs1490931437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP9 Phe136Leu/Phe136Phe SNPs (heterozygotes) increases the risk for mild AP (odds ratio, 3.616; 95% confidence interval, 1.151-11.364; P < 0.05), whereas the homozygotic genotype of CASP9 Ala28Val decreases risk for mild AP (odds ratio, 0.296; 95% confidence interval, 0.091-0.963; P < 0.05).
|
27984487 |
2017 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of GSTM1 is associated with increased susceptibility for AP, and the GSTP1 Val105Ile SNP is associated with an increased risk for AP in men.
|
27984487 |
2017 |