|
rs1736557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs1736557, which caused an amino acid variation V257M, showed a strong association between ATD-induced agranulocytosis and GD controls after Bonferroni correction (p = 0.011, OR 2.301, 95% CI 1.201-4.409).
|
30814476 |
2019 |
|
rs116855232
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two NUDT15 R139C homozygous patients developed agranulocytosis, severe thrombocytopenia and massive hair loss.
|
30101994 |
2018 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the GSTP1 rs1695 gene polymorphism is associated with granulocytopenia induced by platinum-based drugs.
|
30238837 |
2018 |
|
rs2228391
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs, rs2596487 (OR = 4.196, 95% CI = 2.086-8.441, P = 2.08 × 10<sup>-5</sup>) and rs2228391 (OR = 3.621, 95% CI = 1.596-8.217, P = 1.2 × 10<sup>-3</sup>), were independently associated with ATD-induced agranulocytosis.
|
28931918 |
2017 |
|
rs2596487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs, rs2596487 (OR = 4.196, 95% CI = 2.086-8.441, P = 2.08 × 10<sup>-5</sup>) and rs2228391 (OR = 3.621, 95% CI = 1.596-8.217, P = 1.2 × 10<sup>-3</sup>), were independently associated with ATD-induced agranulocytosis.
|
28931918 |
2017 |
|
rs114291795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Agranulocytosis induced by non-chemotherapy drugs in general was significantly associated with the HLA region on chromosome 6, with odds ratios (ORs) of 3·24 (95% CI 2·31-4·55, p=1·20 × 10(-11)) for HLA-B*27:05 and 3·57 (2·61-4·90, p=2·32 × 10(-15)) for the top SNP (rs114291795).
|
27157822 |
2016 |
|
rs185386680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP), rs185386680, showed the strongest association with ATD-induced agranulocytosis in GWAS (odds ratio (OR) = 36.4; 95% confidence interval (CI) = 12.8-103.7; P = 1.3 × 10(-24)) and replication (OR = 37; 95% CI = 3.7-367.4; P = 9.6 × 10(-7)).
|
26599303 |
2016 |
|
rs1127354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TPMT gene was found to have a wild-type sequence in all patients, but in the ITPA gene a mutation, 94C>A, was detected at a rate of 50% (8/16), with 83.3% (5/6) occurring in patients with acute bone marrow suppression and 75% (3/4) in those with agranulocytosis.
|
19214663 |
2009 |