|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ALDH2 rs671 polymorphism is proven to be closely related to the prevalence of CAD, hypertension, diabetes mellitus and alcoholism, which are etiological factors of heart failure.
|
27742538 |
2017 |
|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Data presented show that antialcohol drugs that inhibit Aldh2 gene expression can be generated endogenously in liver cells infected by an adenoviral vector carrying an antisense-coding gene, thus mimicking the high-acetaldehyde phenotype that exists in humans carrying the Glu487Lys mutation who are protected against alcoholism.
|
16131845 |
2005 |
|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.
|
24277619 |
2014 |
|
rs1789891
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Recent genome-wide systematic searches found associations between a single nucleotide polymorphism (rs1789891, risk allele: A, protective allele: C) in the alcohol dehydrogenase gene cluster and the risk of alcohol dependence.
|
29058369 |
2019 |
|
rs1789891
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders.
|
26013422 |
2015 |
|
rs750338
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
|
rs2066702
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
rs2066702
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In a genome-wide association study (GWAS), we identified highly significant associations between two population-specific functional variants in the alcohol dehydrogenase 1B gene (ADH1B) and AD in African-Americans (AAs; rs2066702) and European-Americans (EAs; rs1229984).
|
25828809 |
2016 |
|
rs10196867
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>).
|
31462767 |
2019 |
|
rs139438618
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Under the linear regression model, rs139438618 at the semaphorin 3A (SEMA3A [OMIM 603961]) locus was significantly associated with AD and MD comorbidity in African American participants in the Yale-Penn 1 sample (β = 0.89; 95% CI, 0.57-1.20; P = 2.76 × 10-8).
|
29071344 |
2017 |
|
rs147247472
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>).
|
31462767 |
2019 |
|
rs1614972
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations.
|
23516558 |
2013 |
|
rs2133896
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified and replicated three novel loci that were associated with the common risk of heroin, methamphetamine addiction, and alcoholism: ANKS1B rs2133896 (P<sub>meta</sub> = 3.60 × 10<sup>-9</sup>), AGBL4 rs147247472 (P<sub>meta</sub> = 3.40 × 10<sup>-12</sup>), and CTNNA2 rs10196867 (P<sub>meta</sub> = 4.73 × 10<sup>-9</sup>).
|
31462767 |
2019 |
|
rs2168784
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Carriers of the minor allele of rs2168784 had 1.5 times the hazard of AD onset as compared with those homozygous for the major allele.
|
24962325 |
2014 |
|
rs2173201
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs.
|
24889829 |
2014 |
|
rs34997829
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The clinical relevance of the result was confirmed by the significant interaction between LHPP rs34997829 and AD with respect to self-reported sexually transmitted disease (STD; z=-2.809, p=4.97 × 10<sup>-3</sup>).
|
27531626 |
2017 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Asn40Asp variant (A118G) of the μ opioid receptor (OPRM1) gene is thought to contribute to the development and treatment of alcohol dependence.
|
22397905 |
2013 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPRM1), A118G (Asn40Asp), may moderate naltrexone (NTX) effects in alcohol dependence.
|
23032071 |
2013 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This paper will review converging lines of evidence on the effect of the Asn40Asp SNP on alcoholism phenotypes, including: (i) genetic association studies; (ii) behavioral studies of alcoholism; (iii) neuroimaging studies; (iv) pharmacogenetic studies and clinical trials; and (v) preclinical animal studies.
|
21895723 |
2012 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we compared the frequencies of the polymorphism OPRM1 A118G between patients with alcohol dependence and healthy control subjects living in a Japanese provincial prefecture.
|
16679777 |
2006 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The OPRM1 A118G polymorphism may contribute to the susceptibility of alcohol dependence in Asians but not in Caucasians.
|
22071118 |
2012 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The A118G (rs 1799971) polymorphism in the mu-opioid receptor gene (OPRM1) has been reported to be associated with alcohol addiction.
|
23254216 |
2013 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384).
|
23729673 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The OPRM1 (rs1799971) polymorphism was investigated in an association study of a group of ADS patients (n = 177) and in subgroups (delirium tremens and/or seizures, age at onset <26 years, dissocial alcoholics, positive familial history of alcoholism, delirium tremens, and seizures).
|
30085428 |
2019 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.
|
29070014 |
2017 |