|
rs3849942
|
|
|
0.870 |
GeneticVariation |
GWASDB |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
|
rs3849942
|
|
A |
0.870 |
GeneticVariation |
GWASCAT |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
|
rs3849942
|
|
A |
0.870 |
GeneticVariation |
GWASDB |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
|
rs3849942
|
|
A |
0.870 |
GeneticVariation |
GWASCAT |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
|
rs3849942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10(-11)) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS.
|
20801718 |
2010 |
|
rs3849942
|
|
G |
0.870 |
GeneticVariation |
GWASCAT |
In this analysis, two single nucleotide polymorphisms in a locus on chromosome 9p21.2 were associated with ALS: rs3849942 (p=2·22×10(-6); odds ratio [OR] 1·39, 95% CI 1·21-1·59) and rs2814707 (p=3·32×10(-6); 1·38, 1·20-1·58).
|
20801717 |
2010 |
|
rs3849942
|
|
|
0.870 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs3849942
|
|
|
0.870 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs1541160
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients.
|
24838185 |
2014 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Recently, four single nucleotide polymorphisms (SNPs), including rs2814707 in the 9p21, rs12608932 in the UNC13A gene, rs13048019 in the TIMA1 gene, and rs2228576 in the SCNN1A gene have been reported to be associated with the risk for developing amyotrophic lateral sclerosis (ALS) in Caucasian population.
|
24493373 |
2014 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
|
23587638 |
2013 |
|
rs1541160
|
|
|
0.830 |
GeneticVariation |
BEFREE |
The incidence of the UMN-ALS phenotype in the CC patients of this cohort supports the hypothesis that the SNP rs1541160 within the KIFAP3 gene is a potential modifier of the ALS phenotype.
|
21659726 |
2011 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
BEFREE |
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians.
|
21295378 |
2011 |
|
rs1541160
|
|
|
0.830 |
GeneticVariation |
BEFREE |
It was recently reported that rs1541160 on chromosome 1q24.2 has a marked effect on survival of amyotrophic lateral sclerosis (ALS) patients by influencing KIFAP3 expression.
|
20566859 |
2010 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In the joint analysis, which included samples from 4312 patients with ALS and 8425 control individuals, rs3849942 (p=4·64×10(-10); OR 1·22, 95% CI 1·15-1·30) and rs2814707 (p=4·72×10(-10); 1·22, 1·15-1·30) were associated with ALS.
|
20801717 |
2010 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
|
20801718 |
2010 |
|
rs1541160
|
|
C |
0.830 |
GeneticVariation |
GWASCAT |
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
|
19451621 |
2009 |
|
rs1541160
|
|
C |
0.830 |
GeneticVariation |
GWASDB |
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
|
19451621 |
2009 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs2814707
|
|
|
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.
|
19734901 |
2009 |
|
rs10260404
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls.
|
19525032 |
2011 |
|
rs10260404
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The rs10260404 is not associated with ALS susceptibility in Chinese people with Han origin which may be due to ethnic differences.
|
20137488 |
2009 |
|
rs10260404
|
|
C |
0.820 |
GeneticVariation |
GWASDB |
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
|
18084291 |
2008 |
|
rs10260404
|
|
C |
0.820 |
GeneticVariation |
GWASCAT |
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
|
18084291 |
2008 |
|
rs13048019
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Recently, four single nucleotide polymorphisms (SNPs), including rs2814707 in the 9p21, rs12608932 in the UNC13A gene, rs13048019 in the TIMA1 gene, and rs2228576 in the SCNN1A gene have been reported to be associated with the risk for developing amyotrophic lateral sclerosis (ALS) in Caucasian population.
|
24493373 |
2014 |