|
rs200222843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Apolipoprotein B-100 Hopkins (arginine4019----tryptophan). A new apolipoprotein B-100 variant in a family with premature atherosclerosis and hyperapobetalipoproteinemia.
|
2778934 |
1989 |
|
rs268
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We investigated associations of LPL polymorphisms (HindIII, PvuII, Ser447-->Ter) and the newly described mutation Asn291-->Ser with the risk of myocardial infarction (MI), severity of atherosclerosis, and fasting plasma lipoprotein concentrations in the ECTIM study (614 patients and 733 controls).
|
8576640 |
1995 |
|
rs268
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We now show in approximately 1 in 20 males with proven atherosclerosis that an Asn291Ser mutation in the human lipoprotein lipase (LPL) gene is associated with significantly reduced HDL levels (P = 0.001) and results in a significant decrease in LPL catalytic activity (P < 0.0009).
|
7647785 |
1995 |
|
rs268
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies.
|
9264476 |
1997 |
|
rs267606661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In relatives of the proband, APOE R112; R251G was consistently found in subjects with both hyperlipidemia and atherosclerosis.
|
9360638 |
1997 |
|
rs1799945
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To test whether genetic haemochromatosis is associated with increased atherosclerosis, we determined the prevalence of two mutations in the HFE gene related to haemochromatosis (845G-->A; Cys282Tyr. and 187 C-->G, His63Asp) in 265 consecutive patients with premature (<50 years of age) angiographically-proven atherosclerotic disease (coronary and/or peripheral), and in 272 healthy controls.
|
9753040 |
1998 |
|
rs11542041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Thus, comparisons between the 2/2 and 3/3 mice unequivocally demonstrate that a single amino acid difference (Arg158 Cys) in the apoE protein is sufficient to cause type III HLP and spontaneous atherosclerosis in mice.
|
9649566 |
1998 |
|
rs11542041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have investigated the interaction of apolipoprotein E2(Arg158-Cys) (apoE2) and apolipoprotein E3-Leiden (apoE3-Leiden) with the very low density lipoprotein (VLDL) receptor in vivo and in vitro to define the possible role of this receptor in lipoprotein metabolism and atherosclerosis.
|
9445249 |
1998 |
|
rs879254693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have investigated the interaction of apolipoprotein E2(Arg158-Cys) (apoE2) and apolipoprotein E3-Leiden (apoE3-Leiden) with the very low density lipoprotein (VLDL) receptor in vivo and in vitro to define the possible role of this receptor in lipoprotein metabolism and atherosclerosis.
|
9445249 |
1998 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined associations between the endothelial nitric oxide synthase (eNOS) gene Glu-298-->Asp (894G-->T) mutation and the occurrence and severity of angiographically defined coronary artery disease (CAD). eNOS mediates basal vascular wall nitric oxide production, and altered nitric oxide production has been implicated in atherosclerosis.
|
10475066 |
1999 |
|
rs5361
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs1458766475
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs5355
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs5882
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The effects of two common polymorphisms of CETP, TaqIB in intron 1 and isoleucine 405 to valine (I405-->V) in exon 14, were examined in a sample of 822 men age 18-28 years from 11 countries in Europe who had participated in a study (the European Atherosclerosis Research Study II) of the offspring of myocardial infarction sufferers before the age of 55 years and age-matched control subjects.
|
10092998 |
1999 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A missense gene mutation with methione-to-threonine amino acid substitution at codon 235 (M235T) of angiotensinogen (AGT) has been associated with higher plasma AGT levels and may influence the pathogenesis of cardiac hypertrophy and atherosclerosis.
|
10342781 |
1999 |
|
rs140808909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
|
9925654 |
1999 |
|
rs879254840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
|
9925654 |
1999 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with reduced enzyme activity, hyperhomocysteinaemia and increased risk for atherosclerosis in homozygotes.
|
11094304 |
2000 |
|
rs1799945
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The finding of a similar prevalence of Cys282Tyr and His63Asp mutations in the HFE gene among controls and patients with coronary atherothrombotic disease, indirectly questions the possibility of an association between hereditary hemochromatosis and atherosclerosis.
|
10719381 |
2000 |
|
rs11542041
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158-->Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice.
|
10634808 |
2000 |
|
rs1800562
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The description of two mutations in the HFE gene (Cys282Tyr and His63Asp) related to hereditary hemochromatosis provides an opportunity to address the question of the association between iron overload and atherosclerosis.
|
10719381 |
2000 |
|
rs1346044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.
|
11186893 |
2000 |
|
rs539179964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.
|
11186893 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Reduced vasorelaxations were associated with increased number of clinical risk factors for atherosclerosis (r = - 0.54, P < 0.001), whereas the Glu298Asp variant was not associated with any differences in contractions to phenylephrine, NO-mediated vasorelaxations to acetylcholine, bradykinin or calcium ionophore, or relaxations to the NO donor sodium nitroprusside.
|
11298374 |
2001 |
|
rs5361
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |