|
rs501120
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our results do not confirm an association of the CXCL12 rs501120 polymorphism with atherosclerosis or with CV disease in RA.
|
22386691 |
2012 |
|
rs501120
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genome-wide association studies have revealed two loci (rs1746048 and rs501120) on chromosome 10q11.21 associated with atherosclerosis.
|
23666823 |
2013 |
|
rs1746048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genome-wide association studies have revealed two loci (rs1746048 and rs501120) on chromosome 10q11.21 associated with atherosclerosis.
|
23666823 |
2013 |
|
rs1867624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified 25 new SNP-CAD associations (P < 5 × 10<sup>-8</sup>, in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315).
|
28530674 |
2017 |
|
rs1878406
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results do not confirm association between ABO rs579459, PPAP2B rs17114036, ADAMTS7 rs3825807, PIK3CG rs17398575, and EDNRA rs1878406 and subclinical atherosclerosis and CV disease in RA.
|
24795506 |
2014 |
|
rs2107595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of <i>HDAC9</i> via E2F3 and Rb1.
|
31500558 |
2019 |
|
rs2943634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors.
|
23659870 |
2013 |
|
rs2943641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors.
|
23659870 |
2013 |
|
rs2943650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors.
|
23659870 |
2013 |
|
rs2972146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors.
|
23659870 |
2013 |
|
rs3939286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA.
|
26571131 |
2015 |
|
rs4552883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs representing a block of linkage disequilibrium, rs3789875, rs12347433, and rs4552883, were significantly associated with atherosclerosis in multiple datasets and demonstrated consistent, but suggestive, genetic effects in all analyses.
|
21298289 |
2011 |
|
rs7833904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Risk factors of CAD and clinical phenotype of atherosclerosis were not associated with genotype variants of the rs7833904 SNP.
|
25944972 |
2015 |
|
rs8042271
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recently identified locus for coronary artery disease (CAD) tagged by rs8042271 is in a region of tight linkage disequilibrium (LD) between 2 genes (MFGE8, ABHD2) previously linked to atherosclerosis.
|
30861420 |
2019 |
|
rs974819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study attempted to replicate the results for eight of these loci, CDKN2A/B(rs1333049), ADTRP(rs6903956), PDGFD(rs974819), TCF21(rs12190287), COL4A1-A2(rs4773144), HHIPL1(rs2895811), ADAMTS7(rs4380028) and UBE2Z(rs46522), in patients with pathologically defined atherosclerosis of the coronary arteries.
|
24573017 |
2014 |
|
rs2230806
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present meta-analysis suggested that the ABCA1 R219K and M883I polymorphisms were associated with the susceptibility to AS.
|
24466114 |
2014 |
|
rs2230806
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The K allele of the R219K variant was significantly more frequent in FH subjects without premature CHD (0.32, 95% CI 0.27 to 0.37) than in FH subjects with premature CHD (0.25, 95% CI 0.21 to 0.29) (p<0.05), suggesting that the genetic variant R219K in ABCA1 could influence the development and progression of atherosclerosis in FH subjects.
|
12624133 |
2003 |
|
rs2230806
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The R219K polymorphism in the ATP-binding cassette transporter 1 gene ( ABCA1) has been associated with reduced severity of atherosclerosis, fewer coronary events, decreased triglycerides and a trend to increased HDL in men with coronary heart disease (CHD).
|
12700893 |
2003 |
|
rs2230806
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Results indicated that <i>ABCA1</i> R219K polymorphism has no correlation with LI complicated with arteriosclerosis.
|
30112062 |
2018 |
|
rs2066714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present meta-analysis suggested that the ABCA1 R219K and M883I polymorphisms were associated with the susceptibility to AS.
|
24466114 |
2014 |
|
rs2066715
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, there was no significant association between the ABCA1 V825I polymorphism and AS risk.
|
25527331 |
2015 |
|
rs28937313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We compared the consequences of an ABCA1 mutation that produced an apparent lack of atherosclerosis (Tangier family 1, N935S) with an ABCA1 mutation with functional ABCA1 knockout that was associated with severe atherosclerosis (Tangier family 2, Leu(548):Leu(575)-End), using primary and telomerase-immortalized fibroblasts.
|
24196952 |
2013 |
|
rs4149313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Numerous epidemiological studies have evaluated the associations between ATP-binding cassette transporter 1 (ABCA1) R219K (rs2230806) and M883I (rs4149313) polymorphisms and atherosclerosis (AS), but results remain controversial.
|
24466114 |
2014 |
|
rs57137919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings demonstrated that the ABCG1 promoter rs57137919G>A variant had an allele-specific effect on ABCG1 expression and was associated with an increased apoptosis in cholesterol-loaded macrophages, providing functional evidence to explain the reduced risk for atherosclerosis in subjects with the ABCG1 promoter rs57137919A allele as reported in our previous study.
|
24972087 |
2014 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate whether the angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensinogen M235T or angiotensin II receptor type 1 573C/T polymorphism modify the risk of atherosclerosis associated with beta-blocker or ACE-inhibitor therapy.
|
17298481 |
2007 |