rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this hypothesis-generating pilot study of predominantly Caucasian men, the effect on AF response to AAD therapy of rs10033464 at 4q25 varied based on OSA status.
|
24910551 |
2014 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms at chromosome 4q25 (rs2200733, rs10033464) are associated with both lone and typical atrial fibrillation (AF).
|
23178686 |
2013 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In genetic association analyses, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there was a highly statistically significant association between the presence of both common (rs2200733 and rs10033464) and rare variants and AF (unstratified p = 1 × 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p = 7.6 × 10(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p < 0.0001).
|
22818067 |
2012 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In multivariable analysis, the presence of any common single nucleotide polymorphism (rs2200733, rs10033464) at the 4q25 locus was an independent predictor of AF recurrence (hazard ratio 2.1; 95% confidence interval 1.21-3.30; P = .008).
|
23428961 |
2013 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This SNP (rs10033464) was an independent predictor of AF recurrence in the discovery (39% AF recurrence) and validation (38% AF recurrence) cohorts; OR: 3.27, 95% CI: 1.7 to 6, p < 0.001 and OR: 4.3, 95% CI: 1.98 to 9.4, p < 0.001, respectively.
|
22726630 |
2012 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 8 AF risk SNPs genotyped, only rs10033464 SNP at chromosome (chr) 4q25 (near PITX2) was significantly associated with development of AF after multiple risk factor adjustment and multiple testing (adj. odds ratio [OR] 2.27, 95% confidence interval [CI] 1.31-3.94; P = 3.3 x 10-3).
|
29624624 |
2018 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|
19141561 |
2009 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF.
|
31393025 |
2019 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF).
|
25684755 |
2015 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.
|
31169720 |
2019 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both rs2200733 and rs10033464 were also associated with long-term A</span>F (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to 1.66, respectively).
|
21414601 |
2011 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF.
|
27346453 |
2017 |
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence.
|
29240960 |
2018 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
|
19597492 |
2009 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [<i>PITX2</i>] and rs2106261 at chromosome 16q22 [<i>ZFHX3</i>]), which showed modest associations with AF recurrence.
|
30808078 |
2019 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis.
|
31169720 |
2019 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results indicate that rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population.
|
21107608 |
2011 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The ZFHX3 SNP rs2106261 minor allele is associated with lower AF recurrence rate after pulmonary vein isolation.
|
30180182 |
2018 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
|
26267381 |
2015 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085).
|
26272656 |
2015 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the chromosomal regions 4q25 (rs2200733) and 16q22 (rs2106261) associated with AF in genome-wide association studies were genotyped.
|
23132824 |
2013 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, our study investigated the role of genetic variants of ZFHX3 in AF and two SNPs (rs2106261, rs6499600) showed significant associations while rs16971436 conferred a borderline significant association with AF risk in Chinese Han populations.
|
24983873 |
2014 |
rs2106261
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for AF and AF-related phenotypes.
|
28007413 |
2017 |
rs2200733
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our findings show that a common polymorphism on chromosome 4q25 (rs2200733) is an independent predictor of AF recurrence after DCCV and point to a potential role of stratification by genotype.
|
23428961 |
2013 |