|
rs10006327
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
rs10027347
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In this hypothesis-generating pilot study of predominantly Caucasian men, the effect on AF response to AAD therapy of rs10033464 at 4q25 varied based on OSA status.
|
24910551 |
2014 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms at chromosome 4q25 (rs2200733, rs10033464) are associated with both lone and typical atrial fibrillation (AF).
|
23178686 |
2013 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In genetic association analyses, unstratified and stratified according to age of onset of AF and unaffected age >50 years, there was a highly statistically significant association between the presence of both common (rs2200733 and rs10033464) and rare variants and AF (unstratified p = 1 × 10(-8), stratified [age of onset <50 years and unaffected age >50 years] p = 7.6 × 10(-5)) (unstratified p < 0.0001, stratified [age of onset <50 years and unaffected age >50 years] p < 0.0001).
|
22818067 |
2012 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In multivariable analysis, the presence of any common single nucleotide polymorphism (rs2200733, rs10033464) at the 4q25 locus was an independent predictor of AF recurrence (hazard ratio 2.1; 95% confidence interval 1.21-3.30; P = .008).
|
23428961 |
2013 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This SNP (rs10033464) was an independent predictor of AF recurrence in the discovery (39% AF recurrence) and validation (38% AF recurrence) cohorts; OR: 3.27, 95% CI: 1.7 to 6, p < 0.001 and OR: 4.3, 95% CI: 1.98 to 9.4, p < 0.001, respectively.
|
22726630 |
2012 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We discovered that variants previously shown to associate with atrial fibrillation (AF), rs2200733 and rs10033464, significantly associated with IS, with the strongest risk for CES.
|
18991354 |
2008 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 8 AF risk SNPs genotyped, only rs10033464 SNP at chromosome (chr) 4q25 (near PITX2) was significantly associated with development of AF after multiple risk factor adjustment and multiple testing (adj. odds ratio [OR] 2.27, 95% confidence interval [CI] 1.31-3.94; P = 3.3 x 10-3).
|
29624624 |
2018 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The non-coding SNPs rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
|
19141561 |
2009 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Patients with TIMP-1 < 107 ng/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; P = .007), whereas there was no significant difference among those patients with persistent forms of AF.
|
31393025 |
2019 |
|
rs10033464
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Variants conferring risk of atrial fibrillation on chromosome 4q25.
|
17603472 |
2007 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Common single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF).
|
25684755 |
2015 |
|
rs10033464
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Variants conferring risk of atrial fibrillation on chromosome 4q25.
|
17603472 |
2007 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.
|
31169720 |
2019 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both rs2200733 and rs10033464 were also associated with long-term A</span>F (hazard ratio 1.32, 95% CI 1.05 to 1.67, and hazard ratio 1.28, 95% CI 1.00 to 1.66, respectively).
|
21414601 |
2011 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, the rs10033464 (T) allele is associated with the risk of post-CABG AF and the rs2200733 (T) with lone AF.
|
27346453 |
2017 |
|
rs10033464
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence.
|
29240960 |
2018 |
|
rs10163755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included signs related to both ATTRm and ATTRwt such as chronic ischaemic heart disease (rs140226130, p = 2.00 × 10<sup>-6</sup>), heart failure (rs73956431, p = 2.74 × 10<sup>-6</sup>), atrial fibrillation (rs10163755, p = 4.63 × 10<sup>-6</sup>), dysphagia (rs2949506, p = 3.95 × 10<sup>-6</sup>), intestine diseases (rs970866, p = 7.14 × 10<sup>-6</sup>) and anxiety (rs554521234, p = 8.85 × 10<sup>-6</sup>).
|
31659433 |
2019 |
|
rs10165883
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
rs10213171
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
rs10213171
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
rs10240738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a linear regression model and adapting a resampling inference, a decrease in longitudinal QTc variance was found to associate with SNPs near KCNH2 (rs10240738) and KCNJ2 (rs8079702) when adjusted for patient age, gender, AF type, and average QTc.
|
24460807 |
2014 |
|
rs10401969
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs10428132
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this meta-analysis, both rs10428132 at SCN10A (OR=0.73, P=5.7 × 10(-6)) and rs11708996 at SCN5A (OR=0.80, P=0.02) showed a statistically significant decreased risk of AF.
|
24667784 |
2014 |