Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121912666
rs121912666
TP53
0.800 GeneticVariation UNIPROT

dbSNP: rs371409680
rs371409680
TP53
0.700 GeneticVariation UNIPROT

dbSNP: rs587780076
rs587780076
TP53
0.700 GeneticVariation UNIPROT

dbSNP: rs587781525
rs587781525
TP53
0.700 GeneticVariation UNIPROT

dbSNP: rs762846821
rs762846821
TP53
0.700 GeneticVariation UNIPROT

dbSNP: rs1799950
rs1799950
BRCA1
0.010 GeneticVariation BEFREE We have identified a rare sequence variant, A3537G (Ser 1140Gly) in a B cell lymphoma patient and two polymorphisms, A1186G (Gln356Arg) in a brain cancer patient and A3667G (Lys1183Arg) in a germline tumor patient. 10810408

2000
dbSNP: rs80357796
rs80357796
BRCA1
0.010 GeneticVariation BEFREE We have identified a rare sequence variant, A3537G (Ser 1140Gly) in a B cell lymphoma patient and two polymorphisms, A1186G (Gln356Arg) in a brain cancer patient and A3667G (Lys1183Arg) in a germline tumor patient. 10810408

2000
dbSNP: rs121909224
rs121909224
PTEN
T 0.700 GeneticVariation CLINVAR PTEN controls tumor-induced angiogenesis. 11274365

2001
dbSNP: rs1476157710
rs1476157710
WNT10B
0.010 GeneticVariation BEFREE There was no apparent difference of beta-catenin expression profile in brain tumors; however, the sequencing data of beta-catenin showed two mutations on speculative phosphorylation sites, S73F and S23G in astrocytoma. 12049819

2002
dbSNP: rs766727892
rs766727892
TCF7L2
0.010 GeneticVariation BEFREE There was no apparent difference of beta-catenin expression profile in brain tumors; however, the sequencing data of beta-catenin showed two mutations on speculative phosphorylation sites, S73F and S23G in astrocytoma. 12049819

2002
dbSNP: rs867657798
rs867657798
TCF4
0.010 GeneticVariation BEFREE There was no apparent difference of beta-catenin expression profile in brain tumors; however, the sequencing data of beta-catenin showed two mutations on speculative phosphorylation sites, S73F and S23G in astrocytoma. 12049819

2002
dbSNP: rs868162712
rs868162712
TCF4
0.010 GeneticVariation BEFREE There was no apparent difference of beta-catenin expression profile in brain tumors; however, the sequencing data of beta-catenin showed two mutations on speculative phosphorylation sites, S73F and S23G in astrocytoma. 12049819

2002
dbSNP: rs121909235
rs121909235
PTEN
0.010 GeneticVariation BEFREE Together, these findings suggest that the Arg234Gln missense mutation in PTEN has oncogenic properties and predisposes to brain tumours of multiple lineages. 12085208

2002
dbSNP: rs80359183
rs80359183
BRCA2
0.010 GeneticVariation BEFREE One kindred, of Ashkenazi Jewish ancestry, had five members who were diagnosed with breast cancer and two cousins who were BRCA2*6174delT/C3069X compound heterozygotes and had Fanconi anemia and brain tumors. 14559878

2003
dbSNP: rs1802710
rs1802710
DLK1
0.010 GeneticVariation BEFREE Analysis of 47 brain tumors and 55 lymphomas found that 23 and 29 of them were heterozygous for rs1802710, respectively. 15010842

2004
dbSNP: rs1695
rs1695
GSTP1
0.020 GeneticVariation BEFREE No association was observed between the GSTT1 or GSTP1 Ile105Val polymorphism and brain tumor incidence. 15642394

2005
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002). 15950766

2005
dbSNP: rs1131691014
rs1131691014
TP53
0.020 GeneticVariation BEFREE Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002). 15950766

2005
dbSNP: rs878854066
rs878854066
TP53
0.020 GeneticVariation BEFREE Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002). 15950766

2005
dbSNP: rs1057519828
rs1057519828
EGFR
A 0.700 GeneticVariation CLINVAR Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. 17177598

2006
dbSNP: rs1057519829
rs1057519829
EGFR
C 0.700 GeneticVariation CLINVAR Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. 17177598

2006
dbSNP: rs139236063
rs139236063
EGFR
T 0.700 GeneticVariation CLINVAR Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. 17177598

2006
dbSNP: rs149840192
rs149840192
EGFR
T 0.700 GeneticVariation CLINVAR Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. 17177598

2006
dbSNP: rs861539
rs861539
KLC1 ; XRCC3
0.020 GeneticVariation BEFREE We evaluated the association of SNPs Arg194Trp, Arg280His, and Arg399Gln in the X-ray cross-complementing group 1 (XRCC1) and Thr241Met in the X-ray cross-complementing group 3 (XRCC3) DNA repair genes with the risk of brain tumors. 18330515

2008
dbSNP: rs25487
rs25487
XRCC1
0.010 GeneticVariation BEFREE We evaluated the association of SNPs Arg194Trp, Arg280His, and Arg399Gln in the X-ray cross-complementing group 1 (XRCC1) and Thr241Met in the X-ray cross-complementing group 3 (XRCC3) DNA repair genes with the risk of brain tumors. 18330515

2008