Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE Specifically, we found (i) that the genotype distributions of the P53 Arg72Pro between all brain tumors</span> and controls were statistically significant (P < 0.001) as well as their variant allele frequencies between cases and controls (P < 0.001); (ii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas compared with non-astrocytomas (P = 0.002); and (iii) that there was a significant increase in the Arg/Pro heterozygous genotype among high-grade astrocytomas containing transdominant as well as recessive p53 mutations compared with controls (P = 0.002). 15950766

2005
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE We suggest that TP53 Pro47Ser and Arg72Pro polymorphisms and DNA hypermethylation are involved in susceptibility for developing extra-axial brain tumors. 19224462

2009
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs104894229
rs104894229
HRAS ; LRRC56
0.010 GeneticVariation BEFREE Further, one of the patients (c.35G>A; p.(Gly12Asp)) had a myeloproliferative disorder, and one subject (c.34G>C; p.(Gly12Arg)) exhibited an uncharacterized brain tumour. 28594414

2017
dbSNP: rs104894230
rs104894230
HRAS ; LRRC56
0.020 GeneticVariation BEFREE Further, one of the patients (c.35G>A; p.(Gly12Asp)) had a myeloproliferative disorder, and one subject (c.34G>C; p.(Gly12Arg)) exhibited an uncharacterized brain tumour. 28594414

2017
dbSNP: rs104894230
rs104894230
HRAS ; LRRC56
0.020 GeneticVariation BEFREE When expressed under the control of the krt5 gene promoter, KRAS(G12V) induced bra</span>in tumors in ventricular zones (VZ) at low frequency. 25644510

2015
dbSNP: rs1048943
rs1048943
CYP1A1
0.010 GeneticVariation BEFREE The increased risk of brain tumors was evident for CYP1A1 rs2606345 (P = 0.0028; OR = 2.06; 95 % CI, 1.27-3.34) and minor haplotypes rs2606345-rs1048943-rs4646903 in females (global haplotype association P value, 0.0011). 23661361

2013
dbSNP: rs1052576
rs1052576
CASP9
0.010 GeneticVariation BEFREE CASP-9 (rs1052576) mutant A allele seems to be a protective factor for glioma brain tumor. 28870924

2017
dbSNP: rs1057519747
rs1057519747
TP53
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519747
rs1057519747
TP53
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519757
rs1057519757
PIK3R1
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519828
rs1057519828
EGFR
A 0.700 GeneticVariation CLINVAR Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. 17177598

2006
dbSNP: rs1057519829
rs1057519829
EGFR
C 0.700 GeneticVariation CLINVAR Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. 17177598

2006
dbSNP: rs1057519841
rs1057519841
PIK3R1
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519887
rs1057519887
EGFR
AT 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519887
rs1057519887
EGFR
AA 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519888
rs1057519888
EGFR
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519902
rs1057519902
H3-3A
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519903
rs1057519903
H3-3A
0.020 GeneticVariation BEFREE Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive pediatric brain tumors that are characterized by a recurrent mutation (K27M) within the histone H3 encoding genes H3F3A or HIST1H3A/B/C. 30943283

2019
dbSNP: rs1057519903
rs1057519903
H3-3A
0.020 GeneticVariation BEFREE These data suggest that H3 K27M cannot be considered a specific hallmark of grade IV diffuse gliomas and highlight the importance of integrated histomolecular diagnosis in paediatric brain tumors. 27984673

2018
dbSNP: rs1057519904
rs1057519904
H3C11
0.010 GeneticVariation BEFREE Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive pediatric brain tumors that are characterized by a recurrent mutation (K27M) within the histone H3 encoding genes H3F3A or HIST1H3A/B/C. 30943283

2019
dbSNP: rs1057519906
rs1057519906
IDH2
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519906
rs1057519906
IDH2
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs1057519925
rs1057519925
PIK3CA
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016