Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1052133
rs1052133
0.010 GeneticVariation BEFREE Subgroup analyses revealed significant association of OGG1 rs1052133 with rectal cancer risk. 28749454

2017

dbSNP: rs1800471
rs1800471
0.010 GeneticVariation BEFREE Single Nucleotide Polymorphism TGFβ1 R25P Correlates with Acute Toxicity during Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients. 28333014

2017

dbSNP: rs770507184
rs770507184
0.010 GeneticVariation BEFREE Single Nucleotide Polymorphism TGFβ1 R25P Correlates with Acute Toxicity during Neoadjuvant Chemoradiotherapy in Rectal Cancer Patients. 28333014

2017

dbSNP: rs4646903
rs4646903
0.010 GeneticVariation BEFREE Carriers of the CYP1A1 rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. 28273931

2017

dbSNP: rs397507444
rs397507444
0.060 GeneticVariation BEFREE Although the MTHFR A1298C polymorphism was not associated with OS in CRC, this polymorphism was associated with significantly shorter OS in rectal cancer. 28044213

2017

dbSNP: rs17268122
rs17268122
0.010 GeneticVariation BEFREE The screening of ABCC4 rs17268122 tagSNP and the Mandard tumor response in clinical practice may help to identify patients with different rectal cancer prognosis and contribute to an individualized therapeutic decision tree. 28011504

2017

dbSNP: rs1042522
rs1042522
0.030 GeneticVariation BEFREE These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians. 27901479

2017

dbSNP: rs1131691014
rs1131691014
0.020 GeneticVariation BEFREE These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians. 27901479

2017

dbSNP: rs878854066
rs878854066
0.020 GeneticVariation BEFREE These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians. 27901479

2017

dbSNP: rs1799929
rs1799929
0.010 GeneticVariation BEFREE High fried red meat intake associated with NAT2-T341C, G590A, G857A, A845C, and C48</span>1T rapid acetylator allele determines a risk of 2.39 (P=.002), 2.39 (P=.002), 2.37 (P=.002), 2.28 (P=.004), and 2.51 (P=.001), respectively, for colon cancer, whereas in the case of rectal cancer, the risk increased to 7.55 (P<.001), 7.7 (P<.001), 7.83 (P<.001), 7.51 (P<.001), and 8.62 (P<.001), respectively. 27883249

2017

dbSNP: rs1800449
rs1800449
LOX
0.010 GeneticVariation BEFREE The relationship among the lysyl oxidase (LOX) G473A single nucleotide polymorphism (SNP), cigarette smoking and lung, colorectal, colon and rectum cancer susceptibility was studied in 200 cases of lung cancer, 335 cases of colorectal cancer including 130 cases of colon cancer and 205 cases of rectum cancer, and 335 healthy people in Tangshan, China. 27367711

2016

dbSNP: rs1800925
rs1800925
0.010 GeneticVariation BEFREE Can an IL13 -1112 C/T (rs1800925) polymorphism predict responsiveness to neoadjuvant chemoradiotherapy and survival of Chinese Han patients with locally advanced rectal cancer? 27167201

2016

dbSNP: rs4939827
rs4939827
0.020 GeneticVariation BEFREE A significant association of SNP in SMAD7 rs4939827 and CHI3L1 rs4950928 was revealed between the rectal cancer and colon cancer patients. 26779637

2016

dbSNP: rs4950928
rs4950928
0.010 GeneticVariation BEFREE A significant association of SNP in SMAD7 rs4939827 and CHI3L1 rs4950928 was revealed between the rectal cancer and colon cancer patients. 26779637

2016

dbSNP: rs9365723
rs9365723
0.010 GeneticVariation BEFREE Furthermore, we found that rs9365723 was associated with an increased risk only for colon cancer but not rectal cancer (p = 0.009 and p = 0.414, respectively). 26616230

2016

dbSNP: rs397507444
rs397507444
0.060 GeneticVariation BEFREE The pooled analysis results indicated that MTHFR C677T might be correlated with the tumor response to pRCT under the recessive model (CC vs. CTTT) in overall analysis (OR=1.426(1.074-1.894), P=0.014), rectal cancer (OR=1.483(1.102-1.996), P=0.009), and TRG 1-2 vs. 3-5 group (OR=1.423(1.046-1.936), P=0.025), while other polymorphism including MTHFR A1298C, EGFR G497A, and EGFR CA repeat polymorphisms exerted significant association under all genetic models in overall analysis or subgroup analysis. 26456456

2015

dbSNP: rs1217691063
rs1217691063
0.050 GeneticVariation BEFREE The pooled analysis results indicated that MTHFR C677T might be correlated with the tumor response to pRCT under the recessive model (CC vs. CTTT) in overall analysis (OR=1.426(1.074-1.894), P=0.014), rectal cancer (OR=1.483(1.102-1.996), P=0.009), and TRG 1-2 vs. 3-5 group (OR=1.423(1.046-1.936), P=0.025), while other polymorphism including MTHFR A1298C, EGFR G497A, and EGFR CA repeat polymorphisms exerted significant association under all genetic models in overall analysis or subgroup analysis. 26456456

2015

dbSNP: rs750713244
rs750713244
0.010 GeneticVariation BEFREE The pooled analysis results indicated that MTHFR C677T might be correlated with the tumor response to pRCT under the recessive model (CC vs. CTTT) in overall analysis (OR=1.426(1.074-1.894), P=0.014), rectal cancer (OR=1.483(1.102-1.996), P=0.009), and TRG 1-2 vs. 3-5 group (OR=1.423(1.046-1.936), P=0.025), while other polymorphism including MTHFR A1298C, EGFR G497A, and EGFR CA repeat polymorphisms exerted significant association under all genetic models in overall analysis or subgroup analysis. 26456456

2015

dbSNP: rs14035
rs14035
RAN
0.010 GeneticVariation BEFREE Stratified analysis revealed the RAN rs14035 combined CT+TT genotype was associated with decreased CRC risk in male patients without diabetes mellitus (DM) and in patients with rectal cancer. 26147304

2015

dbSNP: rs113488022
rs113488022
0.030 GeneticVariation BEFREE Compared with BRAF wild type, BRAF(V600E) was a risk for poor survival (overall survival; 5 years: 62.3% vs 51.6%, P=0.014; HR 1.43, CI 1.07-1.90, P=0.009), especially in rectal cancer (for DSS, HR: 10.60, CI: 3.04-36.92, P<0.001). 25973534

2015

dbSNP: rs121913377
rs121913377
0.030 GeneticVariation BEFREE Compared with BRAF wild type, BRAF(V600E) was a risk for poor survival (overall survival; 5 years: 62.3% vs 51.6%, P=0.014; HR 1.43, CI 1.07-1.90, P=0.009), especially in rectal cancer (for DSS, HR: 10.60, CI: 3.04-36.92, P<0.001). 25973534

2015

dbSNP: rs17026425
rs17026425
0.700 GeneticVariation GWASCAT A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes. 25866641

2015

dbSNP: rs6854845
rs6854845
0.700 GeneticVariation GWASCAT A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes. 25866641

2015

dbSNP: rs113488022
rs113488022
0.030 GeneticVariation BEFREE Here we report a patient with rectal cancer who carried the novel BRAF mutation VK600-601E, which has analogous molecular functions to those of the conventional BRAF mutation V600E, and may have potential as a prognostic marker for colorectal cancer (CRC). 25636897

2015

dbSNP: rs121913377
rs121913377
0.030 GeneticVariation BEFREE Here we report a patient with rectal cancer who carried the novel BRAF mutation VK600-601E, which has analogous molecular functions to those of the conventional BRAF mutation V600E, and may have potential as a prognostic marker for colorectal cancer (CRC). 25636897

2015