|
rs25487
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We detected the distributions of three single-nucleotide polymorphisms (XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln) in DNA repair genes, and assessed the associations of these genetic polymorphisms with colon and rectal cancer susceptibility as well as evaluated the interactions of gene-gene and gene-environment in a case-control study of an Indian population.
|
20229274 |
2010 |
|
rs13181
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped 1,181 controls and 311 cases (180 colon and 131 rectal cancer) for SNPs in the XRCC1 (Arg194Trp, Arg399Gln), OGG1 (Ser326Cys), PARP (Val762Ala, Lys940Arg), and XPD (Asp312Asn, Lys751Gln) genes.
|
20559012 |
2009 |
|
rs13181
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These interactions were stronger for rectal cancer cases (heterogeneity test P = 0.002 for XPD Asp312Asn and P = 0.03 for XPD Lys751Gln) and remained statistically significant after accounting for multiple testing.
|
19029193 |
2009 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians.
|
27901479 |
2017 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that the TP53 Arg72Pro polymorphism CC genotype may contribute to an increased risk of CRC, especially for rectal cancer and among Asians.
|
27901479 |
2017 |
|
rs4939827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant association of SNP in SMAD7 rs4939827 and CHI3L1 rs4950928 was revealed between the rectal cancer and colon cancer patients.
|
26779637 |
2016 |
|
rs671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study supports that ALDH-2 Glu487Lys polymorphism is associated with significant reduced risks of CRC in population-based samples, and of rectal cancer in males.
|
25573590 |
2015 |
|
rs4939827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined whether inherited risk variants at rs10795668, rs3802842, rs6983267, and rs4939827 exerted a differential effect on colon and rectal cancers in a Romanian hospital based series of 153 CRC cases and 182 non-affected control subjects prospectively recruited between 2007 and 2010.
|
22457859 |
2012 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.
|
20440859 |
2010 |
|
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with CRC and rectal cancer risk.
|
20440859 |
2010 |
|
rs3802842
|
|
|
0.020 |
GeneticVariation |
BEFREE |
At 11q23.1, rs3802842 was significantly associated with rectal cancer risk only among African Americans (odds ratio, 1.34; P = .01); this observation was made in previous studies.
|
20659471 |
2010 |
|
rs3802842
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, we found that rs10795668 was associated with increased risk only in rectal cancer but not colon cancer, and rs3802842 was also significantly associated with advanced stages of CRC.
|
20530476 |
2010 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
P12A PPARgamma did not significantly interact with BMI, WHR, energy intake, and energy expenditure to alter risk of colon or rectal cancer.
|
15860437 |
2005 |
|
rs1805192
|
|
|
0.020 |
GeneticVariation |
BEFREE |
P12A PPARgamma did not significantly interact with BMI, WHR, energy intake, and energy expenditure to alter risk of colon or rectal cancer.
|
15860437 |
2005 |
|
rs671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, with the rectal cancer analysis, the ORs for high alcohol consumption were greater with 487Glu/Lys genotype compared with Glu/Glu, albeit not.
|
12033531 |
2002 |
|
rs2189517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10<sup>-6</sup> ) and rs2189517 (in RAD51B) with rectal cancer risk (p-value = 5.7 × 10<sup>-6</sup> ).
|
31209889 |
2020 |
|
rs10484879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher rs2275913 and rs10484879, and reduced rs3804513 MAF were seen in rectal cancer (RC) tolerant to FOLFOX (T+) compared to (T-) patients.
|
31138901 |
2019 |
|
rs187115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we comprehensively examined the association between CD44 rs187115 variant and cancer risk (breast cancer, cervical cancer, lung cancer, gastric cancer, liver cancer, colon cancer, and rectal cancer) in a central Chinese population.
|
30860617 |
2019 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher rs2275913 and rs10484879, and reduced rs3804513 MAF were seen in rectal cancer (RC) tolerant to FOLFOX (T+) compared to (T-) patients.
|
31138901 |
2019 |
|
rs2632159
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A more pronounced effect was observed in the male subgroup in that <i>PCAT1</i> rs2632159 SNP increased rectal cancer risk by 3.97-fold (<i>P</i>=0.017).
|
31253700 |
2019 |
|
rs3748067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
|
rs3804513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
|
rs5743030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, PMS1 rs4920657, rs5743030, and rs5743100 were associated with overall survival (OS) time of rectal cancer.
|
30590005 |
2019 |