|
rs1057519874
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A point mutation (P29S) in the RAS-related C3 botulinum toxin substrate 1 (RAC1) was considered to be a trigger for melanoma, a form of skin cancer with highest mortality rate.
|
27699663 |
2016 |
|
rs529365517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A point mutation (P29S) in the RAS-related C3 botulinum toxin substrate 1 (RAC1) was considered to be a trigger for melanoma, a form of skin cancer with highest mortality rate.
|
27699663 |
2016 |
|
rs1051740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying three risk polymorphisms of EPHX1 Tyr113His, XPD C156A, and GSTs presented a 400% increased skin cancer risk when compared to those with less than or equal to one polymorphism.
|
26295053 |
2015 |
|
rs1133400
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs1650697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we found that GSTP1 Ile105Val polymorphism was not associated with skin cancer risk.
|
26044055 |
2015 |
|
rs2278952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs3024496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs876660725
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying three risk polymorphisms of EPHX1 Tyr113His, XPD C156A, and GSTs presented a 400% increased skin cancer risk when compared to those with less than or equal to one polymorphism.
|
26295053 |
2015 |
|
rs897453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the discovery population, genetic variants in the one-carbon metabolism genes phosphatidylethanolamine N-methyltransferase (rs2278952, P for interaction = .004; rs897453, P for interaction = .05) and dihydrofolate reductase (rs1650697, P for interaction = .02), the inflammation gene interleukin 10 (rs3024496, P for interaction =.04), and the skin cancer genes inositol polyphosphate-5-phosphatase (INPP5A; rs1133400, P for interaction = .03) and xeroderma pigmentosum complementation group C (rs2228000, P for interaction = .01) significantly modified the association between arsenic and skin lesions after adjustments for multiple comparisons.
|
25759212 |
2015 |
|
rs104894094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the impact of the CDKN2A germinal mutation p.G101W and MC1R variants on gene expression and transcription profiles associated with skin cancer.
|
24742402 |
2014 |
|
rs872071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis indicated that the rs12203592 and rs872071 IRF4 gene polymorphisms are associated with individual susceptibility to skin cancer and haematological malignancies.
|
24906573 |
2014 |
|
rs886041906
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that the CTLA-4 -1661A/G polymorphism is a potential factor for the susceptibility of cancer, especially in gastric cancer, breast cancer and other cancers, and the CTLA-4 60G/A polymorphism is significantly associated with increased skin cancer risk.
|
24376736 |
2013 |
|
rs2228001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent.
|
23244095 |
2012 |
|
rs373917450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.
|
23244095 |
2012 |
|
rs1126809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data confirmed the association of TYR p.R402Q with SK risk in the French population, and support that rare deleterious TYR variants may also play a role in multi-factorial genetic predisposition to SK.
|
21906913 |
2011 |
|
rs25489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the Arg280His polymorphism was associated with an approximate 3.5-fold increase in skin cancer risk in homozygote codominant and recessive models.
|
22110224 |
2011 |
|
rs401681
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the associations between 39 SNPs, including 38 tag-SNPs in telomere-related genes (TERT, TRF1, TRF2, TNKS2, and POT1) and one SNP (rs401681) in the TERT-CLPTM1L locus which has been identified as a susceptibility locus to skin cancer in the previous GWAS, and the risk of skin cancer in a case-control study of Caucasians nested within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls.
|
21116649 |
2011 |
|
rs1353702185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pigmentary phenotypes and skin cancer risk in a nested case-control study within the Nurses' Health Study (NHS) among 219 melanoma cases, 286 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 873 controls, and among controls from other studies.
|
18814047 |
2009 |
|
rs41556519
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, there is marked clinical heterogeneity (including presence or absence of skin cancers or neurological degeneration) in these XPD/R683W patients, thus suggesting a contribution of the second allele.
|
19934020 |
2009 |
|
rs4880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk.
|
17186424 |
2007 |
|
rs749140677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) and the vitamin D receptor (VDR) gene (Fok1, Bsm1 and Cdx2) with skin cancer risk in a nested case-control study within the Nurses' Health Study [219 melanoma, 286 squamous cell carcinoma (SCC), 300 basal cell carcinoma (BCC) and 873 controls].
|
16950800 |
2007 |
|
rs1232547491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These studies have shown that three RHC alleles - Arg151Cys, Arg160Trp and Asp294His - were associated with increased risk in all forms of skin cancer and with penetrance and age of onset in familial melanoma in mutation carriers.
|
12394181 |
2002 |
|
rs1805008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These studies have shown that three RHC alleles - Arg151Cys, Arg160Trp and Asp294His - were associated with increased risk in all forms of skin cancer and with penetrance and age of onset in familial melanoma in mutation carriers.
|
12394181 |
2002 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The data obtained from this meta-analysis suggest that the MTHFR 1298C allele is associated with increased skin cancer risk, particularly BCC; however, no association was observed between the MTHFR C677T polymorphism and skin cancer.
|
25306137 |
2015 |