Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR rac, a novel ras-related family of proteins that are botulinum toxin substrates. 2674130

1989
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells. 3004741

1986
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR The ras gene family and human carcinogenesis. 3283542

1988
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR ras genes. 3304147

1987
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. 6287572

1982
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus. 6287573

1982
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses. 6288698

1982
dbSNP: rs11554290
rs11554290
NRAS
C 0.700 CausalMutation CLINVAR Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. 6587382

1984
dbSNP: rs1057519729
rs1057519729
MAP2K1
C 0.720 CausalMutation CLINVAR RAS signalling is abnormal in a c-raf1 MEK1 double mutant. 7651428

1995
dbSNP: rs121909219
rs121909219
PTEN
T 0.700 CausalMutation CLINVAR Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers. 9598803

1998
dbSNP: rs779179533
rs779179533
TP63
0.010 GeneticVariation BEFREE In NSCLCs, p51 was expressed in most tumors at variable levels and we found three missense and one silent mutations: Gln31His (transactivation domain) in two tumors, Ala148Pro (DNA-binding domain) and Leu248Leu (DNA-binding domain). 10391684

1999
dbSNP: rs121909219
rs121909219
PTEN
T 0.700 CausalMutation CLINVAR Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. 10555148

1999
dbSNP: rs727503093
rs727503093
HRAS ; LRRC56
T 0.700 GeneticVariation CLINVAR Role of the switch II region in the conformational transition of activation of Ha-ras-p21. 10716188

2000
dbSNP: rs1799802
rs1799802
ERCC4
0.010 GeneticVariation BEFREE The frequencies of several amino acid substitutions in XRCC1 (Arg194Trp, Arg280His and Arg399Gln), XRCC3 (Thr241Met), XPD (Ile199Met, His201Tyr, Asp312Asn and Lys751Gln) and XPF (Pro379Ser) genes were studied in 96 non-small-cell lung cancer (NSCLC) cases and in 96 healthy controls matched for age, gender and cigarette smoking. 11285194

2001
dbSNP: rs121913409
rs121913409
CTNNB1
0.010 GeneticVariation BEFREE Among the cell lines, SCLC NCI-H1092 had a mutation from A to G, leading to an Asp to Gly substitution at codon 6, NSCLC HCC15 had a mutation from C to T, leading to a Ser to Phe substitution at codon 45, and NSCLC NCI-H358 had a mutation from A to G, leading to a Thr to Ala substitution at codon 75. 11464291

2001
dbSNP: rs121909219
rs121909219
PTEN
T 0.700 CausalMutation CLINVAR Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. 11504908

2001
dbSNP: rs113488022
rs113488022
BRAF
T 0.800 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913355
rs121913355
BRAF
A 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913355
rs121913355
BRAF
G 0.720 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913357
rs121913357
BRAF
T 0.710 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913348
rs121913348
BRAF
A 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913364
rs121913364
BRAF
C 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs397516896
rs397516896
BRAF
T 0.700 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs397516897
rs397516897
BRAF
T 0.700 GeneticVariation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002