Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045642
rs1045642
ABCB1
0.060 GeneticVariation BEFREE MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer. 22766400

2012
dbSNP: rs1045642
rs1045642
ABCB1
0.060 GeneticVariation BEFREE Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T predict outcome of platinum-based chemotherapies in advanced non-small cell lung cancer: a meta-analysis. 21827803

2011
dbSNP: rs1046175
rs1046175
PAOX
0.010 GeneticVariation BEFREE In conclusion, SFTPB rs7316, rs9752, and PAOX rs1046175 gene polymorphisms affect the diagnostic value of plasma Pro-SFTPB and DAS in patients with Chinese Han NSCLC. 31016788

2019
dbSNP: rs1047768
rs1047768
ERCC5 ; BIVM-ERCC5
0.020 GeneticVariation BEFREE However, rs1047768C>T and rs17655G>C polymorphisms did not influence the PFS and OS of advanced NSCLC. 24615519

2014
dbSNP: rs1047768
rs1047768
ERCC5 ; BIVM-ERCC5
0.020 GeneticVariation BEFREE In conclusion, our study found that polymorphisms in rs1047768 C/T and rs2296147 C/T are associated with response to platinum-based chemotherapy in advanced NSCLC, and XPG polymorphisms could be predictive of prognosis. 23621222

2013
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. 20453058

2010
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963

2004
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. 20453058

2010
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR High frequency of mutations of the PIK3CA gene in human cancers. 15016963

2004
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR PIK3CA mutation status in Japanese lung cancer patients. 16930767

2006
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. 22162589

2012
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. 16906227

2006
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. 22162589

2012
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370

2005
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. 19029981

2008
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. 15647370

2005
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. 18725974

2008
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells. 19513541

2009
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR The PIK3CA gene is mutated with high frequency in human breast cancers. 15254419

2004
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. 16906227

2006
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. 18725974

2008
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. 21430269

2011
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR PIK3CA mutation status in Japanese lung cancer patients. 16930767

2006
dbSNP: rs104886003
rs104886003
PIK3CA
A 0.700 CausalMutation CLINVAR The PIK3CA gene is mutated with high frequency in human breast cancers. 15254419

2004
dbSNP: rs104886003
rs104886003
PIK3CA
C 0.700 CausalMutation CLINVAR Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. 19029981

2008