|
rs1427471466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants that disrupted RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old individual with metachronous CRC (p.Leu61GlufsTer11 mutation), and a 41-year-old individual with CRC (missense p.Val54Leu), but not in controls.
|
27713038 |
2017 |
|
rs1800371
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs1800371
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrast, all genetic models showed no statistical association of TP53 Pro47Ser polymorphism among CRC patients compared with healthy controls.
|
29560751 |
2019 |
|
rs28934575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other three mutations (Arg175Gly, DeltaPro190, and Gly245Ser) have been found in colorectal carcinomas, the last commonly.
|
12010886 |
2002 |
|
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We therefore investigated the anti-tumor properties of a gold(I) <i>N</i>-heterocyclic carbene (NHC) complex-termed MC3-in human colorectal cancer (CRC) cell lines encompassing three different p53 variations: HCT116 wild-type (WT), HCT116 p53<sup>-/-</sup>, and HT-29 (mutant; R273H).
|
31231607 |
2019 |
|
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Finally, lnc273-31 and lnc273-34 were significantly highly expressed in CRC tissues with p53-R273H mutation compared to those with wildtype p53.
|
31455383 |
2019 |
|
rs28934576
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
|
|
|
|
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Our findings indicate the R270H/R273H p53 mutant protein does not manifest definite GOF biological effects in mouse and human CRCs, suggesting possible GOF effects of mutant p53 in cancer phenotypes are likely allele-specific and/or context-dependent.
|
31148594 |
2019 |
|
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The CRC colorectal cancer (CRC) cell lines HCT116 wild-type (wt), HCT116 p53-/-, and HT-29 (mutant; R273H) were employed, covering three different p53 variations.
|
28618116 |
2017 |
|
rs28934578
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs55832599
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs587780071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study is the first study that investigates the relationship among variants of CDKN2 p16 540 C>G, 580 C>T, and MDM2 SNP309 T>G risk of CRC and the development and progression in the Turkish population.
|
23777425 |
2013 |
|
rs746504075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants that disrupted RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old individual with metachronous CRC (p.Leu61GlufsTer11 mutation), and a 41-year-old individual with CRC (missense p.Val54Leu), but not in controls.
|
27713038 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched multiple electronic databases to identify studies investigating the association between the Arg72Pro polymorphism and colorectal cancer.
|
20615891 |
2010 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that R72P variant seems to be associated with high risk for development of CRC but carries low risk for development of UC.
|
20309662 |
2010 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population.
|
22393962 |
2011 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The gene-gene interaction between TP53 Arg72Pro and MDM2 T309G may interact in carcinogenesis of CRC in Chinese, especially in smokers, and this kind of interaction is associated with onset age of CRC.
|
22744426 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC.
|
24337371 |
2014 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unexpectedly no significant association was found between this potential marker TP53 Arg72Pro and CRC (p > 0.05).
|
25537146 |
2015 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.
|
18988302 |
2008 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors.
|
16353134 |
2006 |