|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although overall, rs10757274 did not add substantially to the usefulness of the FRS for predicting future events, it did improve reclassification of CHD risk, and thus may have clinical utility.
|
18250146 |
2008 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).
|
27741513 |
2016 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively).
|
18957718 |
2008 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We confirmed the associations between four polymorphisms and CHD, the rs1151640 polymorphism in the olfactory receptor family 13 subfamily G member 1 (OR13G1) gene (HR 1.14, 95% CI 1.01-1.28, P = 0.03), the rs11881940 polymorphism in the heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1) gene (HR 1.27, 95% CI 1.07-1.51, P = 0.007), the rs3746731 polymorphism in the complement component 1 q subcomponent receptor 1 (CD93) gene (HR 1.26, 95% CI 1.06-1.49, P = 0.01), and the rs10757274 polymorphism near the cyclin-dependent kinase N2A and N2B (CDKN2A and CDKN2B) genes (HR 1.39, 95% CI 1.15-1.69, P < 0.001).
|
18599554 |
2008 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274.
|
18925945 |
2008 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism on chromosome 9p21, rs10757274 (9p21 allele), has been shown to predict coronary heart disease (CHD) in whites.
|
20031596 |
2009 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population.
|
25592106 |
2015 |
|
rs10757274
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites.
|
19329499 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study confirms the association between 9p21 (rs1333049) and fatal CHD in a Norwegian population-based cohort.
|
24728607 |
2014 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our case-control study and meta-analysis suggest that rs1333049 is a useful risk marker of CHD.
|
24930384 |
2014 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.
|
28639227 |
2017 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD.
|
31770616 |
2020 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.
|
25257646 |
2015 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study.
|
19171343 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI).
|
20231156 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Independent association of the variant rs1333049 at the 9p21 locus and coronary heart disease.
|
21874923 |
2011 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results showed that 3 SNPs in whites (rs599839, rs1333049, and rs501120; HRRs were 1.10 (P = 0.044), 1.14 (P < 0.001), and 1.14 (P = 0.030), respectively) and 1 SNP in African Americans (rs7250581; HRR = 1.60, P = 0.05) were significantly associated with incident CHD.
|
19955471 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively).
|
18957718 |
2008 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs1333049 on chromosome 9p21.3 was associated with both CHD and stroke (HR=1.20, 95% CI 1.08-1.34 for incident CHD events and 1.15, 0.99-1.34 for incident stroke).
|
18979498 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
|
20400779 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08).
|
26950853 |
2016 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts.
|
22436605 |
2012 |